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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Redirecting T lymphocyte specificity using T cell receptor genes.

Redirecting T cells by transferring T cell receptor (TCR) genes from tumor-associated antigen (TAA)-reactive T cell clones into human peripheral blood lymphocytes (PBL) has therapeutic potential for the treatment of diseases, including cancer. T cell specificity can be altered using retroviruses encoding TCRalpha and TCRbeta chain genes, or chimeric immunoglobulin (cIg) genes containing signaling domains of CD3 zeta or Fc epsilon RI-gamma. This review evaluates recent studies using TCRs and cIgs to redirect T cell specificity and discusses some of the technical and biological hurdles that need to be addressed before these approaches can be successfully used to treat patients.[1]

References

  1. Redirecting T lymphocyte specificity using T cell receptor genes. Kaplan, B.L., Yu, D.C., Clay, T.M., Nishimura, M.I. Int. Rev. Immunol. (2003) [Pubmed]
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