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Gene Review

FCER1G  -  Fc fragment of IgE, high affinity I,...

Homo sapiens

Synonyms: Fc receptor gamma-chain, Fc-epsilon RI-gamma, FcRgamma, FceRI gamma, High affinity immunoglobulin epsilon receptor subunit gamma, ...
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Disease relevance of FCER1G


High impact information on FCER1G


Biological context of FCER1G


Anatomical context of FCER1G


Associations of FCER1G with chemical compounds


Other interactions of FCER1G

  • Expressions of the FCER1G and PGDS, which are considered to be mast cell-specific genes, were upregulated in the ovarian endometriotic lesions as compared to the normal ovarian tissues [15].
  • These results provide direct evidence for the functional relatedness of CD3 zeta and Fc epsilon RI gamma [13].
  • Fc gamma RI has recently been shown to be associated with the signal transducing gamma subunit of the high-affinity IgE receptor (Fc epsilon RI gamma) [3].

Analytical, diagnostic and therapeutic context of FCER1G


  1. Redirecting T lymphocyte specificity using T cell receptor genes. Kaplan, B.L., Yu, D.C., Clay, T.M., Nishimura, M.I. Int. Rev. Immunol. (2003) [Pubmed]
  2. Mast cells lacking the high affinity immunoglobulin E receptor are deficient in Fc epsilon RI gamma messenger RNA. Ryan, J.J., Kinzer, C.A., Paul, W.E. J. Exp. Med. (1995) [Pubmed]
  3. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. Wang, A.V., Scholl, P.R., Geha, R.S. J. Exp. Med. (1994) [Pubmed]
  4. Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI). Bieber, T., de la Salle, H., Wollenberg, A., Hakimi, J., Chizzonite, R., Ring, J., Hanau, D., de la Salle, C. J. Exp. Med. (1992) [Pubmed]
  5. Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors. Novak, N., Tepel, C., Koch, S., Brix, K., Bieber, T., Kraft, S. J. Clin. Invest. (2003) [Pubmed]
  6. Physical association between the high-affinity IgG receptor (Fc gamma RI) and the gamma subunit of the high-affinity IgE receptor (Fc epsilon RI gamma). Scholl, P.R., Geha, R.S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  7. Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation. Nambiar, M.P., Fisher, C.U., Kumar, A., Tsokos, C.G., Warke, V.G., Tsokos, G.C. J. Immunol. (2003) [Pubmed]
  8. Involvement of Alu sequences in the cell-specific regulation of transcription of the gamma chain of Fc and T cell receptors. Brini, A.T., Lee, G.M., Kinet, J.P. J. Biol. Chem. (1993) [Pubmed]
  9. Platelet-induced expression of Fc gamma RIII (CD16) on human monocytes. Phillips, J.H., Chang, C.W., Lanier, L.L. Eur. J. Immunol. (1991) [Pubmed]
  10. The human natural killer cell receptor for major histocompatibility complex class I molecules. Surface modulation of p58 molecules and their linkage to CD3 zeta chain, Fc epsilon RI gamma chain and the p56lck kinase. Bottino, C., Vitale, M., Olcese, L., Sivori, S., Morelli, L., Augugliaro, R., Ciccone, E., Moretta, L., Moretta, A. Eur. J. Immunol. (1994) [Pubmed]
  11. Differential activation of the tyrosine kinases ZAP-70 and Syk after Fc gamma RI stimulation. Taylor, N., Jahn, T., Smith, S., Lamkin, T., Uribe, L., Liu, Y., Durden, D.L., Weinberg, K. Blood (1997) [Pubmed]
  12. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. Maurer, D., Fiebiger, S., Ebner, C., Reininger, B., Fischer, G.F., Wichlas, S., Jouvin, M.H., Schmitt-Egenolf, M., Kraft, D., Kinet, J.P., Stingl, G. J. Immunol. (1996) [Pubmed]
  13. CD3 zeta subunit can substitute for the gamma subunit of Fc epsilon receptor type I in assembly and functional expression of the high-affinity IgE receptor: evidence for interreceptor complementation. Howard, F.D., Rodewald, H.R., Kinet, J.P., Reinherz, E.L. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  14. Quantitation of tryptase, chymase, Fc epsilon RI alpha, and Fc epsilon RI gamma mRNAs in human mast cells and basophils by competitive reverse transcription-polymerase chain reaction. Xia, H.Z., Kepley, C.L., Sakai, K., Chelliah, J., Irani, A.M., Schwartz, L.B. J. Immunol. (1995) [Pubmed]
  15. Role of immunoreactions and mast cells in pathogenesis of human endometriosis--morphologic study and gene expression analysis. Konno, R., Yamada-Okabe, H., Fujiwara, H., Uchiide, I., Shibahara, H., Ohwada, M., Ihara, T., Sugamata, M., Suzuki, M. Hum. Cell (2003) [Pubmed]
  16. Physical and functional association of Fc mu receptor on human natural killer cells with the zeta- and Fc epsilon RI gamma-chains and with src family protein tyrosine kinases. Rabinowich, H., Manciulea, M., Metes, D., Sulica, A., Herberman, R.B., Corey, S.J., Whiteside, T.L. J. Immunol. (1996) [Pubmed]
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