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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, T-Cell Receptor

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Disease relevance of Genes, T-Cell Receptor

  • OBJECTIVE--To evaluate the role of candidate genes in the susceptibility to multiple sclerosis (MS) and describe the role of T-cell receptor (TCR) gene rearrangements in the MS brain lesion in identifying a major target of the immune response in this disease [1].
  • A variety of rearranged variable TCR genes was found in polymyositis, V alpha 1, V alpha 5, V beta 1, and V beta 15 being the most common (present in 60-100% of patients) [2].
  • Despite resolution of neutropenia, increased populations of T-LGL cells have persisted in all patients during CSA therapy, as shown by morphology and flow cytometry and by the presence of clonal TCR gene rearrangements in four patients' posttreatment blood samples [3].
  • We investigated the arrangement of Ig and T-cell receptor (TCR) genes, together with the involvement of several oncogenes and the tumor-suppressor gene p53, in a panel of primary cutaneous B- and T-cell lymphomas (CBCLs and CTCLs) [4].
  • Finally, karyotype and chromosome painting analyses showed no evidence for TCR gene translocations in p53-deficient thymomas, although abundant aneuploidy involving frequent duplication of certain chromosomes was present [5].

High impact information on Genes, T-Cell Receptor

  • T cell receptor (TCR) transgenic mice have been made from the rearranged TCR genes of several of these, of which that specific for H-Y/Db is the best studied [6].
  • Both HLA and TCR genes have been linked to susceptibility for MS which is widely believed to be mediated by T cells that recognize an as yet unidentified autoantigen [7].
  • The results support the theory that RAG1 and RAG2 were once components of a transposable element, and that the split nature of immunoglobulin and T-cell-receptor genes derives from germline insertion of this element into an ancestral receptor gene soon after the evolutionary divergence of jawed and jawless vertebrates [8].
  • Here we track the outcome of in vivo interactions between B cells and CD4+ T cells that recognize a transgene-encoded autoantigen, hen egg lysozyme (HEL), using cells from mice transgenic for immunoglobulin and T-cell receptor (TCR) genes [9].
  • These findings suggest that D delta 1, D delta 2, and J delta 1 may be among the first TCR gene elements to undergo recombination and that scid T-lineage cells are developmentally arrested during or shortly after this stage of differentiation [10].

Chemical compound and disease context of Genes, T-Cell Receptor


Biological context of Genes, T-Cell Receptor


Anatomical context of Genes, T-Cell Receptor


Associations of Genes, T-Cell Receptor with chemical compounds

  • In the present study, a longitudinal analysis of T cell receptor (TCR) gene usage by CTL clones was performed in a seropositive person using TCR gene sequences as a means of tracking responses to a well-defined epitope in the glycoprotein 41 transmembrane protein [24].
  • Here we report that the lymphocyte-specific protein tyrosine kinase p56lck, when overexpressed in developing thymocytes, provokes a reduction in V beta--D beta rearrangement while permitting normal juxtaposition of other TCR gene segments [25].
  • These findings underscore the role of gut CP in the early extrathymic maturation of CD8alphaalpha+ IEL, including cell-surface expression of alphaEbeta7 integrin, CD3epsilon gene transcription, and TCR gene rearrangements [26].
  • Also, TCR-defective Jurkat T cells transfected with gammadelta TCR genes produced a significant level of IL-2 in response to the pamidronate-pulsed THP-1 cells [27].
  • The TRGV-J and TRDV-D-J rearrangements expressed by IPP-stimulated Aotus and human gammadelta T cells were similar with respect to 1) TCR gene segment usage, 2) a high degree of germline sequence homology of the TCR gene segments used, and 3) the diversity of the CDR3 regions [28].

Gene context of Genes, T-Cell Receptor

  • Moreover, during the IL-2-mediated maturation process rearrangements and expression of both alpha and beta chain TCR genes occurred, and resulted in the acquisition of alpha/beta as well as gamma/delta (either disulphide-linked or non-disulphide-linked) heterodimeric TCR among the pro-T cell progeny [29].
  • We have isolated a full-length human Gata3 cDNA and characterized its role in TCR gene regulation [30].
  • Investigated was whether cotransfection of RAG1 and RAG2 genes in combination with lymphoid transcription factors can induce TCR gene rearrangements in nonlymphoid human cells [31].
  • We show that mouse Dad1 has a broader expression pattern than the TCR genes, in terms of both tissue and temporal specificity [32].
  • Perhaps as a result of reduced proliferation, the accumulation of RAG-2 protein in the DN thymocytes is increased in B7-deficient mice, which may explain the increased expression of TCR gene and accelerated transition of CD25(+)CD44(-) (DN3) to CD25(-)CD44(-) (DN4) stage [33].

Analytical, diagnostic and therapeutic context of Genes, T-Cell Receptor

  • Relapse blast cells were shown to express the common ALL antigen (CD 10) in all cases and an identical clonal IgH or TCR gene rearrangement was found on PCR analysis of DNA from diagnosis and relapse in all eight cases where DNA extraction was successful [34].
  • V beta 2 TCR expression from these patients was analyzed more extensively using a combination of individual TCR gene cloning, followed by sequence analysis [35].
  • By using Southern blot analysis, the described rearranged TCR genes can be detected in the J alpha junctional region and in the J beta 2 cluster on the genomic DNA level [36].
  • The finding that two gp100-specific TCR, derived from two different CTL, can be functionally introduced into primary human T lymphocytes without loss of the Ag reactivity and peptide fine specificity, holds great promise for the application of TCR gene transfer in cancer immunotherapy [37].
  • Case-specific clonal rearrangements of IgH and TCR genes and expression levels of Wilms' tumor 1 (WT1) mRNA were determined by PCR or RT-PCR methods [38].


  1. Genetic factors in multiple sclerosis. Oksenberg, J.R., Begovich, A.B., Erlich, H.A., Steinman, L. JAMA (1993) [Pubmed]
  2. Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis. Restricted V alpha/beta rearrangements may indicate antigen-driven selection. Mantegazza, R., Andreetta, F., Bernasconi, P., Baggi, F., Oksenberg, J.R., Simoncini, O., Mora, M., Cornelio, F., Steinman, L. J. Clin. Invest. (1993) [Pubmed]
  3. Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells. Sood, R., Stewart, C.C., Aplan, P.D., Murai, H., Ward, P., Barcos, M., Baer, M.R. Blood (1998) [Pubmed]
  4. Molecular analysis of cutaneous B- and T-cell lymphomas. Neri, A., Fracchiolla, N.S., Roscetti, E., Garatti, S., Trecca, D., Boletini, A., Perletti, L., Baldini, L., Maiolo, A.T., Berti, E. Blood (1995) [Pubmed]
  5. No requirement for V(D)J recombination in p53-deficient thymic lymphoma. Liao, M.J., Zhang, X.X., Hill, R., Gao, J., Qumsiyeh, M.B., Nichols, W., Van Dyke, T. Mol. Cell. Biol. (1998) [Pubmed]
  6. The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning. Simpson, E., Scott, D., Chandler, P. Annu. Rev. Immunol. (1997) [Pubmed]
  7. Immunological aspects of demyelinating diseases. Martin, R., McFarland, H.F., McFarlin, D.E. Annu. Rev. Immunol. (1992) [Pubmed]
  8. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Agrawal, A., Eastman, Q.M., Schatz, D.G. Nature (1998) [Pubmed]
  9. CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Rathmell, J.C., Cooke, M.P., Ho, W.Y., Grein, J., Townsend, S.E., Davis, M.M., Goodnow, C.C. Nature (1995) [Pubmed]
  10. T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination. Carroll, A.M., Bosma, M.J. Genes Dev. (1991) [Pubmed]
  11. The polymerase chain reaction in the diagnosis of early mycosis fungoides. Liebmann, R.D., Anderson, B., McCarthy, K.P., Chow, J.W. J. Pathol. (1997) [Pubmed]
  12. Novel aerobic tetracycline resistance gene that chemically modifies tetracycline. Speer, B.S., Salyers, A.A. J. Bacteriol. (1989) [Pubmed]
  13. No restriction of intrathyroidal T cell receptor V alpha families in the thyroid of Graves' disease. McIntosh, R.S., Watson, P.F., Pickerill, A.P., Davies, R., Weetman, A.P. Clin. Exp. Immunol. (1993) [Pubmed]
  14. Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Hoffman, E.S., Passoni, L., Crompton, T., Leu, T.M., Schatz, D.G., Koff, A., Owen, M.J., Hayday, A.C. Genes Dev. (1996) [Pubmed]
  15. Long-term expression of a T-cell receptor beta-chain gene in mice reconstituted with retrovirus-infected hematopoietic stem cells. Kang, J., Wither, J., Hozumi, N. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  16. N-terminal truncated human RAG1 proteins can direct T-cell receptor but not immunoglobulin gene rearrangements. Noordzij, J.G., Verkaik, N.S., Hartwig, N.G., de Groot, R., van Gent, D.C., van Dongen, J.J. Blood (2000) [Pubmed]
  17. Transcription and recombination of the murine RS element. Daitch, L.E., Moore, M.W., Persiani, D.M., Durdik, J.M., Selsing, E. J. Immunol. (1992) [Pubmed]
  18. Synergy between T cell receptor beta gene polymorphism and HLA-DR4 in susceptibility to rheumatoid arthritis. Mu, H., Charmley, P., King, M.C., Criswell, L.A. Arthritis Rheum. (1996) [Pubmed]
  19. Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class-II-expressing thymic stromal cells. Oosterwegel, M.A., Haks, M.C., Jeffry, U., Murray, R., Kruisbeek, A.M. Immunity (1997) [Pubmed]
  20. Transcription of unrearranged antigen receptor genes in scid mice. Schuler, W., Schuler, A., Lennon, G.G., Bosma, G.C., Bosma, M.J. EMBO J. (1988) [Pubmed]
  21. Transcription factor NF-kappa B regulates Ig lambda light chain gene rearrangement. Bendall, H.H., Sikes, M.L., Oltz, E.M. J. Immunol. (2001) [Pubmed]
  22. Immature and advanced patterns of T cell receptor gene rearrangement among lymphocytes in splenic culture. Hurwitz, J.L., Samaridis, J., Pelkonen, J. J. Immunol. (1989) [Pubmed]
  23. Extrathymic TCR gene rearrangement in human small intestine: identification of new splice forms of recombination activating gene-1 mRNA with selective tissue expression. Bas, A., Hammarström, S.G., Hammarström, M.L. J. Immunol. (2003) [Pubmed]
  24. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. Kalams, S.A., Johnson, R.P., Trocha, A.K., Dynan, M.J., Ngo, H.S., D'Aquila, R.T., Kurnick, J.T., Walker, B.D. J. Exp. Med. (1994) [Pubmed]
  25. Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. Anderson, S.J., Abraham, K.M., Nakayama, T., Singer, A., Perlmutter, R.M. EMBO J. (1992) [Pubmed]
  26. Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells. Oida, T., Suzuki, K., Nanno, M., Kanamori, Y., Saito, H., Kubota, E., Kato, S., Itoh, M., Kaminogawa, S., Ishikawa, H. J. Immunol. (2000) [Pubmed]
  27. Essential requirement of antigen presentation by monocyte lineage cells for the activation of primary human gamma delta T cells by aminobisphosphonate antigen. Miyagawa, F., Tanaka, Y., Yamashita, S., Minato, N. J. Immunol. (2001) [Pubmed]
  28. Functional and structural similarity of V gamma 9V delta 2 T cells in humans and Aotus monkeys, a primate infection model for Plasmodium falciparum malaria. Daubenberger, C.A., Salomon, M., Vecino, W., Hübner, B., Troll, H., Rodriques, R., Patarroyo, M.E., Pluschke, G. J. Immunol. (2001) [Pubmed]
  29. Involvement of the interleukin 2 pathway in the rearrangement and expression of both alpha/beta and gamma/delta T cell receptor genes in human T cell precursors. Toribio, M.L., de la Hera, A., Borst, J., Marcos, M.A., Márquez, C., Alonso, J.M., Bárcena, A., Martínez, C. J. Exp. Med. (1988) [Pubmed]
  30. The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Marine, J., Winoto, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  31. Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells. Langerak, A.W., Wolvers-Tettero, I.L., van Gastel-Mol, E.J., Oud, M.E., van Dongen, J.J. Blood (2001) [Pubmed]
  32. A targeted mutation at the T-cell receptor alpha/delta locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dad1. Hong, N.A., Cado, D., Mitchell, J., Ortiz, B.D., Hsieh, S.N., Winoto, A. Mol. Cell. Biol. (1997) [Pubmed]
  33. B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus. Zheng, X., Gao, J.X., Chang, X., Wang, Y., Liu, Y., Wen, J., Zhang, H., Zhang, J., Liu, Y., Zheng, P. J. Immunol. (2004) [Pubmed]
  34. Late relapsing childhood lymphoblastic leukemia. Vora, A., Frost, L., Goodeve, A., Wilson, G., Ireland, R.M., Lilleyman, J., Eden, T., Peake, I., Richards, S. Blood (1998) [Pubmed]
  35. Molecular analysis of T-cell receptor repertoire in bone marrow transplant recipients: evidence for oligoclonal T-cell expansion in graft-versus-host disease lesions. Liu, X., Chesnokova, V., Forman, S.J., Diamond, D.J. Blood (1996) [Pubmed]
  36. T cell receptor alpha and beta gene expression in a murine antigen-specific T suppressor lymphocyte clone with cytolytic potential. Heuer, J., Degwert, J., Pauels, H.G., Kölsch, E. J. Immunol. (1991) [Pubmed]
  37. Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes. Schaft, N., Willemsen, R.A., de Vries, J., Lankiewicz, B., Essers, B.W., Gratama, J.W., Figdor, C.G., Bolhuis, R.L., Debets, R., Adema, G.J. J. Immunol. (2003) [Pubmed]
  38. Lack of clinical utility of minimal residual disease detection in allogeneic stem cell recipients with childhood acute lymphoblastic leukemia: multi-institutional collaborative study in Japan. Imashuku, S., Terui, K., Matsuyama, T., Asami, K., Tsuchiya, S., Ishii, E., Kawa, K., Kosaka, Y., Eguchi, H., Tsuchida, M., Ikuta, K., Kato, S., Koizumi, S., Okamura, J., Morimoto, A., Hibi, S., Hamaoka, K. Bone Marrow Transplant. (2003) [Pubmed]
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