Molecular mechanisms that regulate auditory hair-cell differentiation in the mammalian cochlea.
Mechanosensory hair cells of the vertebrate cochlea offer an excellent developmental system to study cell-fate specification, and to gain insight into the many human neurological deficits which result in a hearing loss, by affecting primarily the hair cells. Therefore, there is great interest in studying the molecular mechanisms that regulate their specification and differentiation. Recent studies, based mostly on loss-of-function experiments that target the role of Notch signaling and basic helix-loop-helix genes in inner-ear development have indicated that they can regulate mechanosensory hair cell-fate specification and their initial differentiation.[1]References
- Molecular mechanisms that regulate auditory hair-cell differentiation in the mammalian cochlea. Zine, A. Mol. Neurobiol. (2003) [Pubmed]
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