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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Anxiety sensitivity and 35% CO2 reactivity in patients with panic disorder.

OBJECTIVE: The present study examines the possible relationships between anxiety sensitivity (AS) and reactivity to the 35% carbon dioxide (CO(2)) challenge in panic disorder (PD). METHODS: One-hundred eight patients with PD underwent the 35% CO(2) challenge and completed the Anxiety Sensitivity Index (ASI). Multiple regression analyses were applied to evaluate the role of AS as a predictor of CO(2)-induced anxiety. RESULTS: Fifty-six patients with PD showed high AS scores, whereas 48 showed medium scores and 4 low scores. ASI scores significantly predicted symptomatological reaction to CO(2) but not subjective induced anxiety. CONCLUSION: These findings suggest that the fear of anxiety-related bodily sensations was related to the symptomatological reactivity to CO(2) but did not seem to play a crucial role in the modulation of the subjective anxiogenic/panicogenic response to hypercapnia in patients with PD.[1]

References

  1. Anxiety sensitivity and 35% CO2 reactivity in patients with panic disorder. Perna, G., Romano, P., Caldirola, D., Cucchi, M., Bellodi, L. Journal of psychosomatic research. (2003) [Pubmed]
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