The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan.

Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection of bacteria through Nod molecules remains largely uncharacterized. Here, we show that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine-N-acetylmuramic acid (GlcNAc-MurNAc) tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-kappaB pathway. Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing.[1]

References

  1. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Girardin, S.E., Boneca, I.G., Carneiro, L.A., Antignac, A., Jéhanno, M., Viala, J., Tedin, K., Taha, M.K., Labigne, A., Zähringer, U., Coyle, A.J., DiStefano, P.S., Bertin, J., Sansonetti, P.J., Philpott, D.J. Science (2003) [Pubmed]
 
WikiGenes - Universities