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Finn, D.P. et al.

Finn, Chapman, Jhaveri, Samanta, Manders, Bowden, Matthews, Marsden, Beckett,

The role of the central nucleus of the amygdala in nociception and aversion.

The role of the central nucleus of the amygdala in nociception--conditioned and unconditioned aversion--was studied. Rats received microinjection of vehicle or the N-type Ca2+ channel blocker omega-conotoxin GVIA (0.2 microg/250 nl) into the central amygdaloid nucleus prior to intra-plantar injection of formalin, ultrasound exposure or immediately prior to the acquisition phase of an aversive conditioning trial. Intra-amygdala omega-conotoxin GVIA resulted in an earlier onset of nociceptive response to formalin and increased nociceptive behaviour during the first 5 min. Omega-conotoxin GVIA significantly reduced conditioned freezing behaviour with no effect on ultrasound-induced unconditioned aversive behaviour. These data indicate that N-type Ca2+ channels in the central amygdaloid nucleus play a role in mediating behavioural responses to nociceptive and conditioned aversive stimuli.[1]

References

The role of the central nucleus of the amygdala in nociception and aversion. Finn, D.P., Chapman, V., Jhaveri, M.D., Samanta, S., Manders, T., Bowden, J., Matthews, L., Marsden, C.A., Beckett, S.R. Neuroreport (2003) [Pubmed]

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