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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The link between glutamate and migraine.

Migraine pain-relay centers, including the trigeminal ganglion, trigeminal nucleus caudalis, and thalamus, contain glutamate-positive neurons, and glutamate activates the trigeminal nucleus caudalis. Glutamate is implicated in cortical spreading depression, trigeminovascular activation, and central sensitization. Glutamate receptor-subtype antagonists are effective in preclinical models of migraine, and in the clinic. These preclinical and clinical observations argue for a strong link between migraine and the glutamatergic system, a link that is important to further characterize in an effort to better understand migraine mechanisms and deliver effective therapies.[1]

References

  1. The link between glutamate and migraine. Ramadan, N.M. CNS spectrums. (2003) [Pubmed]
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