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MeSH Review

Trigeminal Ganglion

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Disease relevance of Trigeminal Ganglion


High impact information on Trigeminal Ganglion

  • Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells [6].
  • Thymidine kinase-positive virus, however, replicated well in ocular tissues as well as in trigeminal ganglion [1].
  • Particularly striking was restoration of near-normal trigeminal ganglion replication and neurovirulence of an ICP34.5 mutant in IFN-alpha/betaR-/- mice [7].
  • The replication of these viruses was examined in eyes and trigeminal ganglia for 1-7 d after corneal inoculation in mice with null mutations (-/-) in interferon receptors (IFNR) for type I IFNs (IFN-alpha/betaR), type II IFN (IFN-gammaR), and both type I and type II IFNs (IFN-alpha/beta/gammaR) [7].
  • Intracisternal A and C particles in mouse neurons: a thin-section study of normal trigeminal ganglion and C1300 neuroblastoma [8].

Chemical compound and disease context of Trigeminal Ganglion


Biological context of Trigeminal Ganglion


Anatomical context of Trigeminal Ganglion

  • NT-3, NT-4, and more prominently BDNF, induce neurite outgrowth from explant cultures of the E10 trigeminal ganglia but no neurites are induced by NGF, despite the expression of trkA [18].
  • In lumbar dorsal root ganglia and trigeminal ganglia, abundant LNGFR mRNA was found in all neurons with strong 125I-NGF labeling and on additional neurons lacking high-affinity NGF-binding sites [19].
  • Previous studies have shown that most neurons in cultures established during the early stages of neurogenesis in the embryonic mouse trigeminal ganglion are supported by BDNF whereas most neurons cultured from older ganglia survive with NGF [20].
  • Early sensory neurons cultured from the trigeminal ganglia of bcl-2-/- embryos at embryonic day 11 (E11) and E12 underwent this change more slowly than trigeminal neurons of wild-type embryos of the same ages [21].
  • Pharmacological experiments using selective Y1 and Y2 receptor antagonists suggest that Y2 is the prominent NPY receptor subtype expressed in trigeminal ganglia neurons, DRG neurons, and spinal cord [16].

Associations of Trigeminal Ganglion with chemical compounds


Gene context of Trigeminal Ganglion


Analytical, diagnostic and therapeutic context of Trigeminal Ganglion


  1. Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus. Tenser, R.B., Miller, R.L., Rapp, F. Science (1979) [Pubmed]
  2. Neurotransmitters and the fifth cranial nerve: is there a relation to the headache phase of migraine? Moskowitz, M.A., Reinhard, J.F., Romero, J., Melamed, E., Pettibone, D.J. Lancet (1979) [Pubmed]
  3. Initial tract formation in the mouse brain. Easter, S.S., Ross, L.S., Frankfurter, A. J. Neurosci. (1993) [Pubmed]
  4. Role of the hypothalamic pituitary adrenal axis and IL-6 in stress-induced reactivation of latent herpes simplex virus type 1. Noisakran, S., Halford, W.P., Veress, L., Carr, D.J. J. Immunol. (1998) [Pubmed]
  5. Correlation between precolonization of trigeminal ganglia by attenuated strains of pseudorabies virus and resistance to wild-type virus latency. Schang, L.M., Kutish, G.F., Osorio, F.A. J. Virol. (1994) [Pubmed]
  6. Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells. Mason, R.T., Peterfreund, R.A., Sawchenko, P.E., Corrigan, A.Z., Rivier, J.E., Vale, W.W. Nature (1984) [Pubmed]
  7. Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo. Leib, D.A., Harrison, T.E., Laslo, K.M., Machalek, M.A., Moorman, N.J., Virgin, H.W. J. Exp. Med. (1999) [Pubmed]
  8. Intracisternal A and C particles in mouse neurons: a thin-section study of normal trigeminal ganglion and C1300 neuroblastoma. Herrlinger, H., Anzil, A.P., Stavrou, D., Heumann, R., Hamprecht, B., Blinzinger, K. J. Natl. Cancer Inst. (1975) [Pubmed]
  9. Retrograde tracing of nerve fibers to the rat middle cerebral artery with true blue: colocalization with different peptides. Edvinsson, L., Hara, H., Uddman, R. J. Cereb. Blood Flow Metab. (1989) [Pubmed]
  10. Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice. Spivack, J.G., O'Boyle, D.R., Fraser, N.W. J. Virol. (1987) [Pubmed]
  11. Genetic studies exposing the splicing events involved in herpes simplex virus type 1 latency-associated transcript production during lytic and latent infection. Alvira, M.R., Goins, W.F., Cohen, J.B., Glorioso, J.C. J. Virol. (1999) [Pubmed]
  12. Cyclic nucleotide modulation of herpes simplex virus latency and reactivation. Sainz de la Maza, M., Wells, P.A., Foster, C.S. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  13. Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development. Rebeck, G.W., Maynard, K.I., Hyman, B.T., Moskowitz, M.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  14. Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development. Piñón, L.G., Middleton, G., Davies, A.M. Development (1997) [Pubmed]
  15. Requirement of neurotrophin-3 for the survival of proliferating trigeminal ganglion progenitor cells. elshamy, W.M., Ernfors, P. Development (1996) [Pubmed]
  16. Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury. Mantyh, P.W., Allen, C.J., Rogers, S., DeMaster, E., Ghilardi, J.R., Mosconi, T., Kruger, L., Mannon, P.J., Taylor, I.L., Vigna, S.R. J. Neurosci. (1994) [Pubmed]
  17. Ectopic expression of DNA encoding IFN-alpha 1 in the cornea protects mice from herpes simplex virus type 1-induced encephalitis. Noisakran, S., Campbell, I.L., Carr, D.J. J. Immunol. (1999) [Pubmed]
  18. Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth. Arumäe, U., Pirvola, U., Palgi, J., Kiema, T.R., Palm, K., Moshnyakov, M., Ylikoski, J., Saarma, M. J. Cell Biol. (1993) [Pubmed]
  19. Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: responses to injury and infusion of NGF. Verge, V.M., Merlio, J.P., Grondin, J., Ernfors, P., Persson, H., Riopelle, R.J., Hökfelt, T., Richardson, P.M. J. Neurosci. (1992) [Pubmed]
  20. Developmental changes in the response of trigeminal neurons to neurotrophins: influence of birthdate and the ganglion environment. Enokido, Y., Wyatt, S., Davies, A.M. Development (1999) [Pubmed]
  21. Bcl-2 accelerates the maturation of early sensory neurons. Middleton, G., Piñón, L.G., Wyatt, S., Davies, A.M. J. Neurosci. (1998) [Pubmed]
  22. A rapid capsaicin-activated current in rat trigeminal ganglion neurons. Liu, L., Simon, S.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  23. Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists. Levy, D., Jakubowski, M., Burstein, R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  24. Subarachnoid blood and headache: altered trigeminal tachykinin gene expression. Linnik, M.D., Sakas, D.E., Uhl, G.R., Moskowitz, M.A. Ann. Neurol. (1989) [Pubmed]
  25. Glutamate receptor subunits GluR5 and KA-2 are coexpressed in rat trigeminal ganglion neurons. Sahara, Y., Noro, N., Iida, Y., Soma, K., Nakamura, Y. J. Neurosci. (1997) [Pubmed]
  26. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. Markowitz, S., Saito, K., Moskowitz, M.A. J. Neurosci. (1987) [Pubmed]
  27. Absence of the p75 neurotrophin receptor alters the pattern of sympathosensory sprouting in the trigeminal ganglia of mice overexpressing nerve growth factor. Walsh, G.S., Krol, K.M., Kawaja, M.D. J. Neurosci. (1999) [Pubmed]
  28. Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion. Ibáñez, C.F., Ernfors, P., Timmusk, T., Ip, N.Y., Arenas, E., Yancopoulos, G.D., Persson, H. Development (1993) [Pubmed]
  29. Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling. Piñon, L.G., Minichiello, L., Klein, R., Davies, A.M. Development (1996) [Pubmed]
  30. Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development. Buchman, V.L., Sporn, M., Davies, A.M. Development (1994) [Pubmed]
  31. Expression of glial fibrillary acidic protein in the CNS and PNS of murine globoid cell leukodystrophy, the twitcher. Kobayashi, S., Chiu, F.C., Katayama, M., Sacchi, R.S., Suzuki, K., Suzuki, K. Am. J. Pathol. (1986) [Pubmed]
  32. Enkephalin convertase: localization to specific neuronal pathways. Lynch, D.R., Strittmatter, S.M., Venable, J.C., Snyder, S.H. J. Neurosci. (1986) [Pubmed]
  33. PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. Ramakrishnan, R., Levine, M., Fink, D.J. J. Virol. (1994) [Pubmed]
  34. Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. Cantin, E.M., Hinton, D.R., Chen, J., Openshaw, H. J. Virol. (1995) [Pubmed]
  35. Analysis of a herpes simplex virus type 1 LAT mutant with a deletion between the putative promoter and the 5' end of the 2.0-kilobase transcript. Maggioncalda, J., Mehta, A., Fraser, N.W., Block, T.M. J. Virol. (1994) [Pubmed]
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