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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

High-yield immobilization of a puromycin analogue for the solid support synthesis of aminoacyl-tRNA fragments.

[reaction: see text] An efficient procedure for the immobilization of 3'-deoxy-3'-(O-methyltyrosyl)aminoadenosine was developed. A poly(ethylene glycol)-derived diacid linker/spacer was attached to aminomethyl polystyrene. Coupling of the 2'-hydroxy instead of the 2'-O-succinylated ribonucleoside resulted in high immobilization yields (over 80%) and allowed for the recovery of valuable unreacted material. This specific procedure should be applicable to other ribonucleosides containing a bulky modification at the 3'-position and can be used for the stepwise construction of 3'-aminoacyl- or 3'-peptidyl-RNA conjugates.[1]

References

  1. High-yield immobilization of a puromycin analogue for the solid support synthesis of aminoacyl-tRNA fragments. Nguyen-Trung, N.Q., Terenzi, S., Scherer, G., Strazewski, P. Org. Lett. (2003) [Pubmed]
 
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