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Nelson, M.L. et al.

Nelson, Ismail, McIntyre, Bhatia, Viski, Hawkins, Rennie, Andorsky, Messersmith, Stapleton, Dumornay, Sheahan, Verma, Warchol, Levy,

Versatile and facile synthesis of diverse semisynthetic tetracycline derivatives via Pd-catalyzed reactions.

A diverse collection of tetracycline derivatives has been synthesized utilizing Heck, Suzuki, and other palladium-coupling reactions via tetracycline arenediazonium and iodoarene salts. Large numbers of tetracyclines are now possible via these reactions, including numerous upper periphery derivatives of doxycycline, minocycline, sancycline, and methacycline modified at positions C7, C9, and C6- C13 on the tetracycline naphthacene ring. Application of palladium-coupling reactions to the tetracyclines has yielded new tetracycline classes with differing structural attributes, greatly increasing the structural diversity of this family of antibiotics, one of the last of the early antibiotic families to be expanded by organic and medicinal chemistry.[1]

References

Versatile and facile synthesis of diverse semisynthetic tetracycline derivatives via Pd-catalyzed reactions. Nelson, M.L., Ismail, M.Y., McIntyre, L., Bhatia, B., Viski, P., Hawkins, P., Rennie, G., Andorsky, D., Messersmith, D., Stapleton, K., Dumornay, J., Sheahan, P., Verma, A.K., Warchol, T., Levy, S.B. J. Org. Chem. (2003) [Pubmed]

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