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Chemical Compound Review

LS-187187     (2Z)-2-(amino-hydroxy- methylidene)-4,7...

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Disease relevance of Minomycin


Psychiatry related information on Minomycin


High impact information on Minomycin


Chemical compound and disease context of Minomycin


Biological context of Minomycin


Anatomical context of Minomycin


Associations of Minomycin with other chemical compounds


Gene context of Minomycin


Analytical, diagnostic and therapeutic context of Minomycin


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  3. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Chen, M., Ona, V.O., Li, M., Ferrante, R.J., Fink, K.B., Zhu, S., Bian, J., Guo, L., Farrell, L.A., Hersch, S.M., Hobbs, W., Vonsattel, J.P., Cha, J.H., Friedlander, R.M. Nat. Med. (2000) [Pubmed]
  4. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Zhu, S., Stavrovskaya, I.G., Drozda, M., Kim, B.Y., Ona, V., Li, M., Sarang, S., Liu, A.S., Hartley, D.M., Wu, d.u. .C., Gullans, S., Ferrante, R.J., Przedborski, S., Kristal, B.S., Friedlander, R.M. Nature (2002) [Pubmed]
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  6. Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning. Hunter, C.L., Quintero, E.M., Gilstrap, L., Bhat, N.R., Granholm, A.C. Eur. J. Neurosci. (2004) [Pubmed]
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  10. Letter: Minocycline activity against tetracycline-resistant Staphylococcus aureus. Leigh, D.A. Lancet (1975) [Pubmed]
  11. Minocycline compared with doxycycline in the treatment of nongonococcal urethritis and mucopurulent cervicitis. Romanowski, B., Talbot, H., Stadnyk, M., Kowalchuk, P., Bowie, W.R. Ann. Intern. Med. (1993) [Pubmed]
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  13. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Yrjänheikki, J., Tikka, T., Keinänen, R., Goldsteins, G., Chan, P.H., Koistinaho, J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  14. Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group. Tilley, B.C., Alarcón, G.S., Heyse, S.P., Trentham, D.E., Neuner, R., Kaplan, D.A., Clegg, D.O., Leisen, J.C., Buckley, L., Cooper, S.M., Duncan, H., Pillemer, S.R., Tuttleman, M., Fowler, S.E. Ann. Intern. Med. (1995) [Pubmed]
  15. Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Wang, X., Zhu, S., Drozda, M., Zhang, W., Stavrovskaya, I.G., Cattaneo, E., Ferrante, R.J., Kristal, B.S., Friedlander, R.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Du, Y., Ma, Z., Lin, S., Dodel, R.C., Gao, F., Bales, K.R., Triarhou, L.C., Chernet, E., Perry, K.W., Nelson, D.L., Luecke, S., Phebus, L.A., Bymaster, F.P., Paul, S.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  17. Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases. Power, C., Henry, S., Del Bigio, M.R., Larsen, P.H., Corbett, D., Imai, Y., Yong, V.W., Peeling, J. Ann. Neurol. (2003) [Pubmed]
  18. Minocycline and black thyroid. Billano, R.A., Ward, W.Q., Little, W.P. JAMA (1983) [Pubmed]
  19. Diversity of melanoma plasma membrane proteinases: inhibition of collagenolytic and cytolytic activities by minocycline. Zucker, S., Lysik, R.M., Ramamurthy, N.S., Golub, L.M., Wieman, J.M., Wilkie, D.P. J. Natl. Cancer Inst. (1985) [Pubmed]
  20. Inflammation is detrimental for neurogenesis in adult brain. Ekdahl, C.T., Claasen, J.H., Bonde, S., Kokaia, Z., Lindvall, O. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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  22. Thyroid gland pigmentation and minocycline therapy. Gordon, G., Sparano, B.M., Kramer, A.W., Kelly, R.G., Iatropoulos, M.J. Am. J. Pathol. (1984) [Pubmed]
  23. Treatment of recurrent thyroid cysts by injection of tetracycline or minocycline. Lee, J.K., Tai, F.T., Lin, H.D., Chou, Y.H., Kaplan, M.M., Ching, K.N. Arch. Intern. Med. (1989) [Pubmed]
  24. Regulation of cytoplasmic calcium concentration in tetracycline-treated osteoclasts. Donahue, H.J., Iijima, K., Goligorsky, M.S., Rubin, C.T., Rifkin, B.R. J. Bone Miner. Res. (1992) [Pubmed]
  25. Symptomatic hepatic cysts: treatment with single-shot injection of minocycline hydrochloride. Cellier, C., Cuenod, C.A., Deslandes, P., Auroux, J., Landi, B., Siauve, N., Barbier, J.P., Frija, G. Radiology. (1998) [Pubmed]
  26. HLA-DRB1 genes and disease severity in rheumatoid arthritis. The MIRA Trial Group. Minocycline in Rheumatoid Arthritis. Reveille, J.D., Alarcón, G.S., Fowler, S.E., Pillemer, S.R., Neuner, R., Clegg, D.O., Mikhail, I.S., Trentham, D.E., Leisen, J.C., Bluhm, G., Cooper, S.M., Duncan, H., Tuttleman, M., Heyse, S.P., Sharp, J.T., Tilley, B. Arthritis Rheum. (1996) [Pubmed]
  27. Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion. Fox, C., Dingman, A., Derugin, N., Wendland, M.F., Manabat, C., Ji, S., Ferriero, D.M., Vexler, Z.S. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  28. Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell-microglia interaction. Giuliani, F., Hader, W., Yong, V.W. J. Leukoc. Biol. (2005) [Pubmed]
  29. Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha. Sriram, K., Miller, D.B., O'Callaghan, J.P. J. Neurochem. (2006) [Pubmed]
  30. Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia. Nikodemova, M., Duncan, I.D., Watters, J.J. J. Neurochem. (2006) [Pubmed]
  31. Tetracycline-resistant Ureaplasma urealyticum: a cause of persistent nongonococcal urethritis. Stimson, J.B., Hale, J., Bowie, W.R., Holmes, K.K. Ann. Intern. Med. (1981) [Pubmed]
  32. Inhibition of autoimmune encephalomyelitis by a tetracycline. Popovic, N., Schubart, A., Goetz, B.D., Zhang, S.C., Linington, C., Duncan, I.D. Ann. Neurol. (2002) [Pubmed]
  33. Minocycline-induced hyperpigmentation masquerading as alkaptonuria in individuals with joint pain. Suwannarat, P., Phornphutkul, C., Bernardini, I., Turner, M., Gahl, W.A. Arthritis Rheum. (2004) [Pubmed]
  34. Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. Scarabelli, T.M., Stephanou, A., Pasini, E., Gitti, G., Townsend, P., Lawrence, K., Chen-Scarabelli, C., Saravolatz, L., Latchman, D., Knight, R., Gardin, J. J. Am. Coll. Cardiol. (2004) [Pubmed]
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