Biochemical targets of nitric oxide-induced toxicity.
Nitric oxide (NO) has become one of the most intensively studied molecules in recent years. Although its beneficial role has been well established, a large body of adverse effects was also attributed to NO and/or its red-ox derivatives, implicating a dual (friend and foe) role of this agent in biological systems. Peroxynitrite (ONOO-), a product from the reaction of NO with superoxide anion (O2.-) was recognized as a potent toxic endogenous agent. This review will discus some of the discrete and/or silent chemical aspects of both NO produced from L-arginine and peroxynitrite in an attempt to elucidate the potential biochemical target(s) of NO- and/or peroxynitrite-induced toxicity.[1]References
- Biochemical targets of nitric oxide-induced toxicity. Grudziński, I.P. Roczniki Państwowego Zakładu Higieny. (2003) [Pubmed]
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