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Khoshoo, V. et al.

Khoshoo, Thoppil, Landry, Brown, Ross,

Propofol versus midazolam plus meperidine for sedation during ambulatory esophagogastroduodenoscopy.

OBJECTIVE: To evaluate the efficacy and safety of propofol and meperidine plus midazolam for sedation during esophagogastroduodenoscopy (EGD) in children. METHODS: Data were collected prospectively and retrospectively from neurologically intact children (0.2-17.7 years of age) who underwent ambulatory diagnostic EGD during a 4-year period. Data were included from 155 consecutive patients receiving propofol with or without premedication with midazolam (PM group). One hundred five consecutive patients who received sedation with a midazolam plus meperidine combination served as a comparison (MM group). Outcome variables were: time required for induction of sedation, length of procedure, time for recovery, need for additional supportive measures, and need for physical restraint. RESULTS: The onset of sedation was faster and the length of procedure and recovery were significantly shorter in the PM group as compared with the MM group (P < 0.01). Patients in the MM group required restraint more often than in the PM group. A higher dose of meperidine and midazolam was used in the prospective study. This led to deeper sedation but increased need for additional support. CONCLUSIONS: Propofol is safe and effective for facilitating EGD in children.[1]

References

Propofol versus midazolam plus meperidine for sedation during ambulatory esophagogastroduodenoscopy. Khoshoo, V., Thoppil, D., Landry, L., Brown, S., Ross, G. J. Pediatr. Gastroenterol. Nutr. (2003) [Pubmed]

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