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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Premedication


Psychiatry related information on Premedication


High impact information on Premedication


Chemical compound and disease context of Premedication


Biological context of Premedication


Anatomical context of Premedication


Associations of Premedication with chemical compounds

  • Even when a narrow instrument is used, patients still benefit from premedication with diazepam, although return to normal activity is slower because of drowsiness [31].
  • We conclude that adverse reactions to Fluosol are probably mediated by C activation and that steroid premedication may prevent them in susceptible patients [32].
  • PURPOSE: To compare the efficacy, characteristics of onset/recovery, and safety of ketamine/atropine/midazolam with meperidine/midazolam used as premedication for painful procedures in children with cancer [33].
  • Each child received intravenous premedication with either meperidine 2 mg/kg and midazolam 0.1 mg/kg (MM) or atropine 0.01 mg/kg, midazolam 0.05 mg/kg, and ketamine 1.5 mg/kg (KM) on one occasion followed by the alternative regimen on a second occasion [33].
  • Premedication with diphenhydramine was instituted for the remainder [34].

Gene context of Premedication


Analytical, diagnostic and therapeutic context of Premedication


  1. Double-blind clinical trial of anaesthetic premedication for use in major day surgery. Prescott, R.J., Espley, A.J., Davie, I.T., Slawson, K.B., Ruckley, C.V. Lancet (1976) [Pubmed]
  2. Hematin: unique effects of hemostasis. Glueck, R., Green, D., Cohen, I., Ts'ao, C.H. Blood (1983) [Pubmed]
  3. Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma. Wiernik, P.H., Schwartz, E.L., Einzig, A., Strauman, J.J., Lipton, R.B., Dutcher, J.P. J. Clin. Oncol. (1987) [Pubmed]
  4. Phase II study of troxacitabine (BCH-4556) in patients with advanced and/or metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada-Clinical Trials Group. Townsley, C.A., Chi, K., Ernst, D.S., Belanger, K., Tannock, I., Bjarnason, G.A., Stewart, D., Goel, R., Ruether, J.D., Siu, L.L., Jolivet, J., McIntosh, L., Seymour, L., Moore, M.J. J. Clin. Oncol. (2003) [Pubmed]
  5. Amphotericin B revisited: reassessment of toxicity. Clements, J.S., Peacock, J.E. Am. J. Med. (1990) [Pubmed]
  6. Changes in noradrenergic neuroendocrine responses following repeated seizures and the mechanism of action of ECT. McWilliam, J.R., Meldrum, B.S., Checkley, S.A. Psychopharmacology (Berl.) (1982) [Pubmed]
  7. Respiratory effects and amnesia after premedication with morphine or lorazepam. Cormack, R.S., Milledge, J.S., Hanning, C.D. British journal of anaesthesia. (1977) [Pubmed]
  8. Atropine premedication and the cardiovascular response to electroconvulsive therapy. Mayur, P.M., Shree, R.S., Gangadhar, B.N., Subbakrishna, D.K., Janakiramaiah, N., Rao, G.S. British journal of anaesthesia. (1998) [Pubmed]
  9. Influence of opioids and naloxone on rhythmic motor activity in spinal cats. Schomburg, E.D., Steffens, H. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1995) [Pubmed]
  10. Spontaneous movement after injection of propofol. Chan, A., Nickoll, E., Thornton, C., Doré, C., Newton, D.E. Anaesthesia. (1996) [Pubmed]
  11. Severe anaphylactoid reaction to radiographic contrast media. Recurrences despites premedication with diphenhydramine and prednisone. Madowitz, J.S., Schweiger, M.J. JAMA (1979) [Pubmed]
  12. Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype. Webster, L., Linsenmeyer, M., Millward, M., Morton, C., Bishop, J., Woodcock, D. J. Natl. Cancer Inst. (1993) [Pubmed]
  13. Intravenous hydrocortisone premedication reduces antibodies to infliximab in Crohn's disease: a randomized controlled trial. Farrell, R.J., Alsahli, M., Jeen, Y.T., Falchuk, K.R., Peppercorn, M.A., Michetti, P. Gastroenterology (2003) [Pubmed]
  14. Vagal stimulation of human gastric bicarbonate secretion. Forssell, H., Stenquist, B., Olbe, L. Gastroenterology (1985) [Pubmed]
  15. Effect of isosorbide and hydralazine in painful primary esophageal motility disorders. Mellow, M.H. Gastroenterology (1982) [Pubmed]
  16. Phase I clinical and pharmacokinetic study of taxol. Wiernik, P.H., Schwartz, E.L., Strauman, J.J., Dutcher, J.P., Lipton, R.B., Paietta, E. Cancer Res. (1987) [Pubmed]
  17. Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel. Ibrahim, N.K., Desai, N., Legha, S., Soon-Shiong, P., Theriault, R.L., Rivera, E., Esmaeli, B., Ring, S.E., Bedikian, A., Hortobagyi, G.N., Ellerhorst, J.A. Clin. Cancer Res. (2002) [Pubmed]
  18. Meptazinol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Holmes, B., Ward, A. Drugs (1985) [Pubmed]
  19. Succinylcholine and atropine for premedication of the newborn infant before nasotracheal intubation: a randomized, controlled trial. Barrington, K.J., Finer, N.N., Etches, P.C. Crit. Care Med. (1989) [Pubmed]
  20. Didemnin B in favourable histology non-Hodgkin's lymphoma. A phase II study of the National Cancer Institute of Canada Clinical Trials Group. Goss, G., Muldal, A., Lohmann, R., Taylor, M., Lopez, P., Armitage, G., Steward, W.P. Investigational new drugs. (1995) [Pubmed]
  21. Inhaled lysine-aspirin as a bronchoprovocation procedure in aspirin-sensitive asthma: its repeatability, absence of a late-phase reaction, and the role of histamine. Phillips, G.D., Foord, R., Holgate, S.T. J. Allergy Clin. Immunol. (1989) [Pubmed]
  22. Effect of an inhaled antihistamine on exercise-induced asthma. Hartley, J.P., Nogrady, S.G. Thorax (1980) [Pubmed]
  23. Pharmacokinetic drug interactions in anaesthetic practice. Wood, M. Clinical pharmacokinetics. (1991) [Pubmed]
  24. Short-term effects of intravenous benzodiazepines on autonomic neurocardiac regulation in humans: a comparison between midazolam, diazepam, and lorazepam. Agelink, M.W., Majewski, T.B., Andrich, J., Mueck-Weymann, M. Crit. Care Med. (2002) [Pubmed]
  25. Premedication with famotidine augments core hypothermia during general anesthesia. Hirose, M., Hara, Y., Matsusaki, M. Anesthesiology (1995) [Pubmed]
  26. Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma. Peterson, A.C., Swiger, S., Stadler, W.M., Medved, M., Karczmar, G., Gajewski, T.F. Clin. Cancer Res. (2004) [Pubmed]
  27. Pentagastrin stimulation of technetium-99m uptake by ectopic gastric muscosa in a Meckel's diverticulum. Treves, S., Grand, R.J., Eraklis, A.J. Radiology. (1978) [Pubmed]
  28. Clonidine and lidocaine inhibition of isoflurane-induced tachycardia in humans. Tanaka, S., Tsuchida, H., Namba, H., Namiki, A. Anesthesiology (1994) [Pubmed]
  29. Effect of midazolam and diazepam premedication on central nervous system and cardiovascular toxicity of bupivacaine in pigs. Bernards, C.M., Carpenter, R.L., Rupp, S.M., Brown, D.L., Morse, B.V., Morell, R.C., Thompson, G.E. Anesthesiology (1989) [Pubmed]
  30. Influence of sepsis on sevoflurane minimum alveolar concentration in a porcine model. Allaouchiche, B., Duflo, F., Tournadre, J.P., Debon, R., Chassard, D. British journal of anaesthesia. (2001) [Pubmed]
  31. Patients appreciate premedication for endoscopy. Thompson, D.G., Lennard-Jones, J.E., Evans, S.J., Cowan, R.E., Murray, R.S., Wright, J.T. Lancet (1980) [Pubmed]
  32. Activation of plasma complement by perfluorocarbon artificial blood: probable mechanism of adverse pulmonary reactions in treated patients and rationale for corticosteroids prophylaxis. Vercellotti, G.M., Hammerschmidt, D.E., Craddock, P.R., Jacob, H.S. Blood (1982) [Pubmed]
  33. Ketamine-midazolam versus meperidine-midazolam for painful procedures in pediatric oncology patients. Marx, C.M., Stein, J., Tyler, M.K., Nieder, M.L., Shurin, S.B., Blumer, J.L. J. Clin. Oncol. (1997) [Pubmed]
  34. Phase II trial of docetaxel in patients with stage III and IV non-small-cell lung cancer. Francis, P.A., Rigas, J.R., Kris, M.G., Pisters, K.M., Orazem, J.P., Woolley, K.J., Heelan, R.T. J. Clin. Oncol. (1994) [Pubmed]
  35. Dexamethasone as a probe for docetaxel clearance. Puisset, F., Chatelut, E., Dalenc, F., Busi, F., Cresteil, T., Azéma, J., Poublanc, M., Hennebelle, I., Lafont, T., Chevreau, C., Roché, H. Cancer Chemother. Pharmacol. (2004) [Pubmed]
  36. Human pancreatic polypeptide, neuropeptide Y and peptide YY reduce the contractile motility by depressing the release of acetylcholine from the myenteric plexus of the guinea pig ileum. Takahashi, T., Yamamura, T., Utsunomiya, J. Gastroenterol. Jpn. (1992) [Pubmed]
  37. Psychological and endocrine responses to psychosocial stress and dexamethasone/corticotropin-releasing hormone in healthy postmenopausal women and young controls: the impact of age and a two-week estradiol treatment. Kudielka, B.M., Schmidt-Reinwald, A.K., Hellhammer, D.H., Kirschbaum, C. Neuroendocrinology (1999) [Pubmed]
  38. Options for the treatment of serious infections with interleukin-1. van der Meer, J.W. Biotherapy (Dordrecht, Netherlands) (1989) [Pubmed]
  39. The response of plasma oxytocin to surgical stress. Nussey, S.S., Page, S.R., Ang, V.T., Jenkins, J.S. Clin. Endocrinol. (Oxf) (1988) [Pubmed]
  40. A randomized Phase II trial of the antiangiogenic agent SU5416 in hormone-refractory prostate cancer. Stadler, W.M., Cao, D., Vogelzang, N.J., Ryan, C.W., Hoving, K., Wright, R., Karrison, T., Vokes, E.E. Clin. Cancer Res. (2004) [Pubmed]
  41. Dilatation of epicardial coronary arteries and attenuation of provoked coronary vasoconstriction by nisoldipine. Gansser, R.E., Bachmann, K.F. Eur. Heart J. (1989) [Pubmed]
  42. Comparative randomized double-blind study of hydroxyzine versus placebo as premedication before injection of iodinated contrast media. Bertrand, P.R., Soyer, P.M., Rouleau, P.J., Alison, D.P., Billardon, M.J. Radiology. (1992) [Pubmed]
  43. Premedication with intravenous ketorolac trometamol (Toradol) in colonoscopy: a randomized controlled trial. Mui, W.L., Kwong, W.H., Li, A.C., Au Yeung, A.C., Poon, C.M., Chiu, P.W., Chan, Y.L., Leong, H.T., Ng, E.K. Am. J. Gastroenterol. (2005) [Pubmed]
  44. Effects of oral clonidine premedication on plasma glucose and lipid homeostasis associated with exogenous glucose infusion in children. Nishina, K., Mikawa, K., Maekawa, N., Shiga, M., Obara, H. Anesthesiology (1998) [Pubmed]
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