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Chemical Compound Review

Demerol     ethyl1-methyl-4-phenyl- piperidine-4...

Synonyms: Dolosal, Pethidine, Dolcontral, Dolsin, meperidine, ...
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Disease relevance of Dolosal


Psychiatry related information on Dolosal

  • In contrast, pethidine provoked a decrease in the RIII,Su threshold and an increase in RIII,Cu threshold, parallel with an increase in pain threshold sensation [6].
  • 3 Pethidine and morphine both increased hot plate reaction times measured after 30 min [7].
  • The number of patients with amnesia for the examination was highest in the meperidine group [8].
  • Thus, meperidine (6.25 mg/kg per h), which has the lowest efficacy of the drugs infused, produced the greatest shift to the right of the stimulus-generalization curves of these three drugs; the post-meperidine PR ranged between 0.40 and 0.61 [9].
  • Propofol provided a significantly better patient cooperation than midazolam/meperidine (p < 0.01), but the procedure tolerability was rated nearly the same by both groups [10].

High impact information on Dolosal


Chemical compound and disease context of Dolosal


Biological context of Dolosal


Anatomical context of Dolosal


Associations of Dolosal with other chemical compounds


Gene context of Dolosal


Analytical, diagnostic and therapeutic context of Dolosal


  1. Reversible parkinsonism related to meperidine. Lieberman, A.N., Goldstein, M. N. Engl. J. Med. (1985) [Pubmed]
  2. Hypersensitivity to meperidine. Waisbren, B.A. JAMA (1978) [Pubmed]
  3. Isoniazid, meperidine, and hypotension. Gannon, R., Pearsall, W., Rowley, R. Ann. Intern. Med. (1983) [Pubmed]
  4. Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer. Szeto, H.H., Inturrisi, C.E., Houde, R., Saal, S., Cheigh, J., Reidenberg, M.M. Ann. Intern. Med. (1977) [Pubmed]
  5. Central nervous system excitatory effects of meperidine in cancer patients. Kaiko, R.F., Foley, K.M., Grabinski, P.Y., Heidrich, G., Rogers, A.G., Inturrisi, C.E., Reidenberg, M.M. Ann. Neurol. (1983) [Pubmed]
  6. Pharmacological modulations on the nociceptive flexion reflex in man. Willer, J.C., Bathien, N. Pain (1977) [Pubmed]
  7. Involvement of 5-hydroxytryptamine in the analgesic action of pethidine and morphine in mice. Botting, R., Morinan, A. Br. J. Pharmacol. (1982) [Pubmed]
  8. Sedation and analgesia for gastrointestinal endoscopy. Chokhavatia, S., Nguyen, L., Williams, R., Kao, J., Heavner, J.E. Am. J. Gastroenterol. (1993) [Pubmed]
  9. Sensitization and tolerance to the discriminative stimulus effects of mu-opioid agonists. Paronis, C.A., Holtzman, S.G. Psychopharmacology (Berl.) (1994) [Pubmed]
  10. Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study. Riphaus, A., Stergiou, N., Wehrmann, T. Am. J. Gastroenterol. (2005) [Pubmed]
  11. Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial. Vargo, J.J., Zuccaro, G., Dumot, J.A., Shermock, K.M., Morrow, J.B., Conwell, D.L., Trolli, P.A., Maurer, W.G. Gastroenterology (2002) [Pubmed]
  12. Influence of hyperalimentation on rat hepatic microsomal fluidity and function. Knodell, R.G., Whitmer, D.I., Holman, R.T. Gastroenterology (1990) [Pubmed]
  13. Substrate-level energy dependence of acid secretion in the isolated human gastric mucosa. Chacín, J., Prieto, A., Cárdenas, P. Gastroenterology (1985) [Pubmed]
  14. Failure of glucagon in the treatment of alcoholic pancreatitis. Olazabal, A., Fuller, R. Gastroenterology (1978) [Pubmed]
  15. Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Moratalla, R., Quinn, B., DeLanney, L.E., Irwin, I., Langston, J.W., Graybiel, A.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  16. Meperidine-induced delirium. Eisendrath, S.J., Goldman, B., Douglas, J., Dimatteo, L., Van Dyke, C. The American journal of psychiatry. (1987) [Pubmed]
  17. Additional minocycline pleurodesis after thoracoscopic surgery for primary spontaneous pneumothorax. Chen, J.S., Hsu, H.H., Chen, R.J., Kuo, S.W., Huang, P.M., Tsai, P.R., Lee, J.M., Lee, Y.C. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  18. A comparison of morphine, pethidine and fentanyl in the postsurgical patient-controlled analgesia environment. Woodhouse, A., Hobbes, A.F., Mather, L.E., Gibson, M. Pain (1996) [Pubmed]
  19. Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. Gillis, J.C., Brogden, R.N. Drugs (1997) [Pubmed]
  20. Narcotic analgesics and delayed gastric emptying during labour. Nimmo, W.S., Wilson, J., Prescott, L.F. Lancet (1975) [Pubmed]
  21. A potentially toxic drug interaction between pethidine (meperidine) and phenobarbitone. Stambaugh, J.E., Hemphill, D.M., Wainer, I.W., Schwartz, I. Lancet (1977) [Pubmed]
  22. [3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study. Higgins, D.S., Greenamyre, J.T. J. Neurosci. (1996) [Pubmed]
  23. Effect of analgesic drugs on the electromyographic activity of the gastrointestinal tract and sphincter of Oddi and on biliary pressure. Coelho, J.C., Senninger, N., Runkel, N., Herfarth, C., Messmer, K. Ann. Surg. (1986) [Pubmed]
  24. Disposition of meperidine in pregnancy. Morgan, D., Moore, G., Thomas, J., Triggs, E. Clin. Pharmacol. Ther. (1978) [Pubmed]
  25. Postoperative demand for analgesics in relation to individual levels of endorphins and substance P in cerebrospinal fluid. Tamsen, A., Sakurada, T., Wahlström, A., Terenius, L., Hartvig, P. Pain (1982) [Pubmed]
  26. Topical lidocaine in preendoscopic medication. Gordon, M.J., Mayes, G.R., Meyer, G.W. Gastroenterology (1976) [Pubmed]
  27. The effects of premedication drugs on the lower oesophageal high pressure zone and reflux status of rhesus monkeys and man. Hall, A.W., Moossa, A.R., Clark, J., Cooley, G.R., Skinner, D.B. Gut (1975) [Pubmed]
  28. Eliminating analgesic meperidine use with a supported formulary restriction. O'Connor, A.B., Lang, V.J., Quill, T.E. Am. J. Med. (2005) [Pubmed]
  29. CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Ramírez, J., Innocenti, F., Schuetz, E.G., Flockhart, D.A., Relling, M.V., Santucci, R., Ratain, M.J. Drug Metab. Dispos. (2004) [Pubmed]
  30. Designer drugs that are potent inhibitors of CYP2D6. Pritzker, D., Kanungo, A., Kilicarslan, T., Tyndale, R.F., Sellers, E.M. Journal of clinical psychopharmacology. (2002) [Pubmed]
  31. Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein. Thompson, S.J., Koszdin, K., Bernards, C.M. Anesthesiology (2000) [Pubmed]
  32. Meperidine attenuates the secretion but not the transcription of interleukin 1 beta in human mononuclear leukocytes. McCarthy, D.O., Murray, S., Galagan, D., Gern, J.E., Hutson, P.R. Nursing research. (1998) [Pubmed]
  33. Meperidine attenuates the febrile response to endotoxin and interleukin-1 alpha in rats. McCarthy, D.O., Daun, J.M., Hutson, P.R. Nursing research. (1993) [Pubmed]
  34. Chronic parkinsonism secondary to intranasal administration of a product of meperidine-analogue synthesis. Wright, J.M., Wall, R.A., Perry, T.L., Paty, D.W. N. Engl. J. Med. (1984) [Pubmed]
  35. The relationship of postoperative delirium with psychoactive medications. Marcantonio, E.R., Juarez, G., Goldman, L., Mangione, C.M., Ludwig, L.E., Lind, L., Katz, N., Cook, E.F., Orav, E.J., Lee, T.H. JAMA (1994) [Pubmed]
  36. Maternal pyrexia associated with the use of epidural analgesia in labour. Fusi, L., Steer, P.J., Maresh, M.J., Beard, R.W. Lancet (1989) [Pubmed]
  37. Small bowel motility following major intra-abdominal surgery: the effects of opiates and rectal cisapride. Benson, M.J., Roberts, J.P., Wingate, D.L., Rogers, J., Deeks, J.J., Castillo, F.D., Williams, N.S. Gastroenterology (1994) [Pubmed]
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