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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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SIR1, an upstream component in auxin signaling identified by chemical genetics.

Auxin is a plant hormone that regulates many aspects of plant growth and development. We used a chemical genetics approach to identify SIR1, a regulator of many auxin-inducible genes. The sir1 mutant was resistant to sirtinol, a small molecule that activates many auxin-inducible genes and promotes auxin-related developmental phenotypes. SIR1 is predicted to encode a protein composed of a ubiquitin- activating enzyme E1-like domain and a Rhodanese-like domain homologous to that of prolyl isomerase. We suggest a molecular context for how the auxin signal is propagated to exert its biological effects.[1]

References

  1. SIR1, an upstream component in auxin signaling identified by chemical genetics. Zhao, Y., Dai, X., Blackwell, H.E., Schreiber, S.L., Chory, J. Science (2003) [Pubmed]
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