Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hay, R.V. et al.

Radioimmunoscintigraphy of tumors autocrine for human met and hepatocyte growth factor/scatter factor.

Inappropriate expression of the c-met-protooncogene product (Met) and/or of its ligand, hepatocyte growth factor/scatter factor ( HGF/ SF), has been correlated with poor prognosis in a variety of human solid tumors. We are developing animal models for nuclear imaging of Met and HGF/ SF expression in tumors in vivo. We radioiodinated a mixture of monoclonal antibodies (MAbs) that bind to human HGF/ SF and to the external ligand-binding domain of human Met, and then injected the I-125-MAb mixture intravenously into mice bearing tumors either autocrine for human HGF/ SF and human Met or autocrine-paracrine for murine HGF/ SF and murine Met. Serial total body gamma camera images were obtained, and regional activity was determined by quantitative region-of-interest (ROI) analysis. Tumors autocrine for human HGF/ SF and Met demonstrated significantly more rapid uptake and more rapid clearance of the I-125-MAb mixture than tumors expressing one or both murine homologues, reaching a mean tumor to total body activity ratio of > 0.3 by 1 day postinjection. We conclude that radioimmunodetection of tumors autocrine for human HGF/ SF and Met is feasible with an I-125-MAb mixture reactive against the ligand-receptor pair.[1]

References

Radioimmunoscintigraphy of tumors autocrine for human met and hepatocyte growth factor/scatter factor. Hay, R.V., Cao, B., Skinner, R.S., Wang, L.M., Su, Y., Resau, J.H., Vande Woude, G.F., Gross, M.D. Molecular imaging : official journal of the Society for Molecular Imaging. (2002) [Pubmed]

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