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MeSH Review


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Disease relevance of Radioimmunodetection


High impact information on Radioimmunodetection


Chemical compound and disease context of Radioimmunodetection


Biological context of Radioimmunodetection

  • Biodistribution and pharmacokinetics of radiolabeled mAb E48 IgG and E48 F(ab')2 were analyzed and compared in 39 patients with histologically proven squamous cell carcinoma of the head and neck who were included in a radioimmunoscintigraphy study and underwent surgery 44 h after injection [16].
  • The advent of biotechnology has made it possible to overcome the undesired host antiglobulin response evidenced following the injection of rodent antibodies for radioimmunoimaging; initially through the construction of chimeric and CDR-grafted antibodies and more recently through the derivation of completely human antibodies [17].

Anatomical context of Radioimmunodetection


Associations of Radioimmunodetection with chemical compounds


Gene context of Radioimmunodetection


Analytical, diagnostic and therapeutic context of Radioimmunodetection


  1. Localization of radiolabeled monoclonal antibody in a human soft tissue sarcoma xenograft. Brown, J.M., Greager, J.A., Pavel, D.G., Gupta, T.K. J. Natl. Cancer Inst. (1985) [Pubmed]
  2. Carcinoembryonic antigen radioimmunodetection in colorectal cancer. Goldenberg, D.M., Deland, F.H. Gastroenterology (1983) [Pubmed]
  3. Breast tumor radioimmunodetection with a 111In-labeled monoclonal antibody (MA5) against a mucin-like antigen. Major, P.P., Dion, A.S., Williams, C.J., Mattes, M.J., Wang, T., Rosenthall, L. Cancer Res. (1990) [Pubmed]
  4. Radioimmunoscintigraphy of head and neck cancer using 99mTc-labeled monoclonal antibody E48 F(ab')2. van Dongen, G.A., Leverstein, H., Roos, J.C., Quak, J.J., van den Brekel, M.W., van Lingen, A., Martens, H.J., Castelijns, J.A., Visser, G.W., Meijer, C.J. Cancer Res. (1992) [Pubmed]
  5. Retargeting interleukin 13 for radioimmunodetection and radioimmunotherapy of human high-grade gliomas. Debinski, W., Thompson, J.P. Clin. Cancer Res. (1999) [Pubmed]
  6. Indium-111 labelled monoclonal antibody to placental alkaline phosphatase in in the detection of neoplasms of testis, ovary, and cervix. Epenetos, A.A., Snook, D., Hooker, G., Begent, R., Durbin, H., Oliver, R.T., Bodmer, W.F., Lavender, J.P. Lancet (1985) [Pubmed]
  7. Carcinoembryonic antigen radioimmunodetection. Dykes, P.W., Bradwell, A.R. Gastroenterology (1983) [Pubmed]
  8. Radioimmunoscintigraphy of colorectal carcinoma using technetium-99m-labeled, totally human monoclonal antibody 88BV59H21-2. Gulec, S.A., Serafini, A.N., Moffat, F.L., Vargas-Cuba, R.D., Sfakianakis, G.N., Franceschi, D., Crichton, V.Z., Subramanian, R., Klein, J.L., De Jager, R.L. Cancer Res. (1995) [Pubmed]
  9. Initial clinical study of indium-111-labeled clone 110 anticarcinoembryonic antigen antibody in patients with colorectal cancer. Griffin, T.W., Brill, A.B., Stevens, S., Collins, J.A., Bokhari, F., Bushe, H., Stochl, M.C., Gionet, M., Rusckowski, M., Stroupe, S.D. J. Clin. Oncol. (1991) [Pubmed]
  10. Carcinoembryonic antigen and alpha-fetoprotein expression and monoclonal antibody targeting in a human hepatoma/nude mouse model. Wang, Z.F., Stein, R., Sharkey, R.M., Goldenberg, D.M. Cancer Res. (1990) [Pubmed]
  11. Radioimmunoscintigraphy of colon cancer with iodine-131-labeled B72.3 monoclonal antibody. Carrasquillo, J.A., Sugarbaker, P., Colcher, D., Reynolds, J.C., Esteban, J., Bryant, G., Keenan, A.M., Perentesis, P., Yokoyama, K., Simpson, D.E. J. Nucl. Med. (1988) [Pubmed]
  12. 99mTc-IMMU-4 monoclonal antibody scan in colorectal cancer. A prospective study. Rodriguez-Bigas, M.A., Bakshi, S., Stomper, P., Blumenson, L.E., Petrelli, N.J. Archives of surgery (Chicago, Ill. : 1960) (1992) [Pubmed]
  13. Detection of occult tumor using indium 111-labeled anticarcinoembryonic antigen antibodies. Halpern, S.E., Dillman, R.O., Amox, D., Hagan, P.L., Burks, R., Dillman, J., Perdikakis, B., Merchant, B., Frincke, J., Schweighardt, S. Archives of surgery (Chicago, Ill. : 1960) (1992) [Pubmed]
  14. 99mTc-CD19 monoclonal antibody is not useful for imaging of B cell non-Hodgkin's lymphoma. Vervoordeldonk, S.F., Heikens, J., Goedemans, W.T., Merle, P.A., von dem Borne, A.E., van Royen, E.A., Slaper-Cortenbach, I.C., van Oers, R.H. Cancer Immunol. Immunother. (1996) [Pubmed]
  15. Initial clinical results with technetium-99m-labeled LL2 monoclonal antibody fragment in the radioimmunodetection of B-cell lymphomas. Baum, R.P., Niesen, A., Hertel, A., Adams, S., Kojouharoff, G., Goldenberg, D.M., Hör, G. Cancer (1994) [Pubmed]
  16. Biodistribution of radiolabeled monoclonal antibody E48 IgG and F(ab')2 in patients with head and neck cancer. de Bree, R., Roos, J.C., Quak, J.J., den Hollander, W., Wilhelm, A.J., van Lingen, A., Snow, G.B., Dongen, G.A. Clin. Cancer Res. (1995) [Pubmed]
  17. Radioimmunoimaging. Advances and prospects. Van de Wiele, C., Revets, H., Mertens, N. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceu... (2004) [Pubmed]
  18. Radioimmunodetection of degranulated human eosinophils in mice: a potential model for imaging Hodgkin's disease and other pathologic conditions. Samoszuk, M.K., Fang, M., Anderson, A.L. J. Nucl. Med. (1991) [Pubmed]
  19. Radioimmunodetection of residual, recurrent or metastatic germ cell tumors using technetium-99 anti-(alpha-fetoprotein) Fab' fragment. Amato, R., Kim, E.E., Prow, D., Andreopoulos, D., Kasi, L.P. J. Cancer Res. Clin. Oncol. (2000) [Pubmed]
  20. Radioimmunoimaging of glomus tympanicum tumors by In-111 labeled monoclonal antibody using single photon emission computed tomography. Kairemo, K.J., Himi, T., Hopsu, E.V., Ramsay, H.A. The American journal of otology. (1997) [Pubmed]
  21. The effect of radioimmunotherapy using murine monoclonal antibody KIS1 on esophageal squamous cell carcinoma-bearing nude mice. Fujii, T., Yamana, H., Toh, Y., Toh, U., Fujita, H., Shirouzu, K., Morimatsu, M. Surgery today. (1997) [Pubmed]
  22. Radioimmunoimaging of venous thrombi using iodine-131 monoclonal antibody. Rosebrough, S.F., Kudryk, B., Grossman, Z.D., McAfee, J.G., Subramanian, G., Ritter-Hrncirik, C.A., Witanowski, L.S., Tillapaugh-Fay, G. Radiology. (1985) [Pubmed]
  23. Radioimmunoimaging of experimental thrombi in dogs using technetium-99m-labeled monoclonal antibody fragments reactive with human platelets. Som, P., Oster, Z.H., Zamora, P.O., Yamamoto, K., Sacker, D.F., Brill, A.B., Newell, K.D., Rhodes, B.A. J. Nucl. Med. (1986) [Pubmed]
  24. Tumor pretargeting: role of avidin/streptavidin on monoclonal antibody internalization. Casalini, P., Luison, E., Ménard, S., Colnaghi, M.I., Paganelli, G., Canevari, S. J. Nucl. Med. (1997) [Pubmed]
  25. Effect of DTPA conjugation on the antigen binding activity and biodistribution of monoclonal antibodies against alpha-fetoprotein. Sakahara, H., Endo, K., Nakashima, T., Koizumi, M., Ohta, H., Torizuka, K., Furukawa, T., Ohmomo, Y., Yokoyama, A., Okada, K. J. Nucl. Med. (1985) [Pubmed]
  26. Perchlorate blocking for radioimmunodetection. Bradwell, A.R., Dykes, P.W., Fairweather, D.S. J. Nucl. Med. (1983) [Pubmed]
  27. Immunological considerations in the use of goat antibodies to carcinoembryonic antigen for the radioimmunodetection of cancer. Primus, F.J., Goldenberg, D.M. Cancer Res. (1980) [Pubmed]
  28. Carcinoembryonic antigen production, secretion, and kinetics in BALB/c mice and a nude mouse-human tumor model. Martin, K.W., Halpern, S.E. Cancer Res. (1984) [Pubmed]
  29. Radioimmunoscintigraphy using monoclonal antibodies to CEA, CA 19-9 and CA 125. Baum, R.P., Lorenz, M., Hottenrott, C., Albrecht, M., Senekowitsch, R., Happ, J., Hertel, A., Spitz, J., Hör, G. Int. J. Biol. Markers (1988) [Pubmed]
  30. Radioimmunoscintigraphy of tumors autocrine for human met and hepatocyte growth factor/scatter factor. Hay, R.V., Cao, B., Skinner, R.S., Wang, L.M., Su, Y., Resau, J.H., Vande Woude, G.F., Gross, M.D. Molecular imaging : official journal of the Society for Molecular Imaging. (2002) [Pubmed]
  31. New approaches to the management of acute and chronic cardiac allograft rejection. Isobe, M., Suzuki, J. Jpn. Circ. J. (1998) [Pubmed]
  32. Clinical value of immunoscintigraphy in colorectal carcinoma patients: a prospective study. Bischof-Delaloye, A., Delaloye, B., Buchegger, F., Gilgien, W., Studer, A., Curchod, S., Givel, J.C., Mosimann, F., Pettavel, J., Mach, J.P. J. Nucl. Med. (1989) [Pubmed]
  33. Radioimmunolocalization of the monoclonal antibody J28 in early transformation stages in N-nitrosobis(2-hydroxypropyl)amine-induced pancreatic tumors in the Syrian golden hamster. Takeda, Y., Miralles, F., Daher, N., Escribano, M.J. J. Cancer Res. Clin. Oncol. (1992) [Pubmed]
  34. Preoperative and intraoperative radioimmunodetection of cancer pretargeted by biotinylated monoclonal antibodies. Di Carlo, V., De Nardi, P., Stella, M., Magnani, P., Fazio, F. Seminars in surgical oncology. (1998) [Pubmed]
  35. Monoclonal antibodies for diagnosis and potential therapy of small cell lung cancer--the ganglioside antigen fucosyl-GM1. Vangsted, A.J., Zeuthen, J. Acta oncologica (Stockholm, Sweden) (1993) [Pubmed]
  36. Direct labeling of monoclonal antibodies with 99mTc and radioimmunodetection of a murine mammary carcinoma with 99mTc-B2C114. Duran, A.P., Asurmendi, S., D'Orio, E., Horenstein, A.L., de Castiglia, S.G. Journal of nuclear biology and medicine (Turin, Italy : 1991) (1994) [Pubmed]
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