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van der Vegt, B.J. et al.

van der Vegt, Lieuwes, van de Wall, Kato, Moya-Albiol, Martínez-Sanchis, de Boer, Koolhaas,

Activation of serotonergic neurotransmission during the performance of aggressive behavior in rats.

High aggression is often linked to lowered serotonin (5-HT) neurotransmission. Although this may hold for high aggression as a trait characteristic of an individual, serotonergic activity is probably increased during performance of aggressive behavior. To test this hypothesis, first, the 5-HT1A agonist alnespirone and gamma aminobutyric acid-A agonist muscimol were administered into the dorsal raphe nucleus. These treatments, which inhibit 5-HT neuronal activity, were shown to decrease performance of aggressive behavior. Second, after a resident-intruder test, the activation of 5-HT neurons (measured by c-fos expression) was increased in high-aggressive rats, compared with low-aggressive rats or control rats that were not subjected to a social confrontation. Results show that performance of aggressive behavior increases 5-HT neuronal activity and that preventing this activation inhibits expression of aggressive behavior.[1]

References

Activation of serotonergic neurotransmission during the performance of aggressive behavior in rats. van der Vegt, B.J., Lieuwes, N., van de Wall, E.H., Kato, K., Moya-Albiol, L., Martínez-Sanchis, S., de Boer, S.F., Koolhaas, J.M. Behav. Neurosci. (2003) [Pubmed]

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