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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors.

Steroid-thyroid hormone receptors typically bind as dimers to DNA sequences that contain repeated elements termed half-sites. NGFI-B, an early response protein and orphan member of this receptor superfamily, binds to a DNA sequence that contains only one half-site (5'-AAAGGTCA-3'). A domain separate from the NGFI-B zinc fingers, termed the A box, was identified and is required for recognition of the two adenine-thymidine (A-T) base pairs at the 5' end of the NGFI-B DNA binding element. In addition, a domain downstream of the zinc fingers of the orphan receptor H-2 region II binding protein, termed the T box, determined binding to tandem repeats of the estrogen receptor half-site (5'-AGGTCA-3').[1]

References

  1. Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors. Wilson, T.E., Paulsen, R.E., Padgett, K.A., Milbrandt, J. Science (1992) [Pubmed]
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