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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD homolog hlh-1.

The myoD family of DNA binding proteins has been implicated in the control of myogenesis in a variety of organisms. Searches for homologs in the nematode Caenorhabditis elegans yielded only one gene, designated hlh-1, expressed in body-wall muscle cells and their precursors. To assess the role of hlh-1 in C. elegans myogenesis, genetic deficiencies spanning the hlh-1 locus were isolated after gamma irradiation. Embryos homozygous for these deficiencies exhibited extensive body-wall muscle differentiation, including expression of several characteristic myofilament proteins and weak contracile behavior. Thus, zygotic hlh-1 expression was not required for body-wall muscle precursors to adopt muscle cell fates.[1]

References

  1. Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD homolog hlh-1. Chen, L., Krause, M., Draper, B., Weintraub, H., Fire, A. Science (1992) [Pubmed]
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