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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells.

A form of the human erythropoietin receptor (EPOR) was identified in which the cytoplasmic region is truncated by alternative splicing. The truncated form of the receptor (EPOR-T) is the most prevalent form of EPOR in early-stage erythroid progenitor cells, but the full-length EPOR (EPOR-F) becomes the most prevalent form in late-stage progenitors. EPOR-T can transduce a mitogenic signal. However, cells transfected with EPOR-T are more prone to programmed cell death than those expressing EPOR-F. EPOR-F may transduce a signal to prevent programmed cell death that is independent of the mitogenic signal, and alternative splicing of the EPOR gene may have an important role in erythropoiesis.[1]

References

  1. A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells. Nakamura, Y., Komatsu, N., Nakauchi, H. Science (1992) [Pubmed]
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