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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Investigation of the mode of inheritance of insulin-dependent diabetes mellitus in Japanese subjects.

Previous studies have shown that insulin-dependent diabetes mellitus is positively associated with HLA-DR4 and HLA-DR9 in Japanese populations. It was proposed that susceptibility to the disease is determined by a single HLA allele associated with both DR4 and DR9. DR genotypes in a Japanese population with insulin-dependent diabetes mellitus were determined by DRB/DQB RFLP analysis. A single disease-susceptibility-allele model was tested by the antigen-genotype-frequency-among-patients method. Recessive and additive inheritance of a single susceptibility allele were rejected. The DR9-associated disease-susceptibility allele in Japanese subjects is distinct from both the DR3- and DR4-associated susceptibility alleles in white Caucasians. The data suggest further complexity in the inheritance of HLA-associated susceptibility to insulin-dependent diabetes mellitus.[1]

References

  1. Investigation of the mode of inheritance of insulin-dependent diabetes mellitus in Japanese subjects. Jenkins, D., Penny, M.A., Uchigata, Y., Jacobs, K.H., Mijovic, C.H., Hirata, Y., Otani, T., Fletcher, J., Bradwell, A.R., Barnett, A.H. Am. J. Hum. Genet. (1992) [Pubmed]
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