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Rubiolo, P. et al.

Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system.

The mutagenicity of a series of pyrrolizidine alkaloids, and of extracts from several Italian Senecio species containing pyrrolizidine alkaloids, including S. inaequidens, S. fuchsii and S. cacaliaster, were tested using the Salmonella typhimurium/mammalian microsome system. Retrorsine, senecivernine, seneciphylline and the Senecio extracts showed a weakly mutagenic activity.[1]

References

Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system. Rubiolo, P., Pieters, L., Calomme, M., Bicchi, C., Vlietinck, A., Vanden Berghe, D. Mutat. Res. (1992) [Pubmed]

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