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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Expression cloning of the murine and human interleukin 9 receptor cDNAs.

Interleukin 9 ( IL-9) is a T-cell-derived lymphokine that induces the proliferation of various lymphoid and hemopoietic cells. A cDNA clone encoding the murine IL-9 receptor was isolated by expression cloning in COS cells and screening with 125I- labeled IL-9. Transient expression of this cDNA produced high-affinity binding sites for IL-9. The predicted 52-kDa protein contains a putative signal peptide and a typical transmembrane domain. A cDNA for the human homologue was isolated by cross-hybridization. Transfection of this cDNA in a murine T-cell clone conferred responsiveness to human IL-9. Sequence analysis revealed that the IL-9 receptor belongs to the recently described hematopoietin receptor super-family and is expressed in membrane-bound and soluble forms.[1]


  1. Expression cloning of the murine and human interleukin 9 receptor cDNAs. Renauld, J.C., Druez, C., Kermouni, A., Houssiau, F., Uyttenhove, C., Van Roost, E., Van Snick, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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