Thrombocytosis in patients with tumors producing colony-stimulating factor.
We investigated the cause of thrombocytosis in 14 patients with tumors producing colony-stimulating factor ( CSF). Of the 14 patients, 10 had tumors producing granulocyte-CSF ( G-CSF) and 4 had tumors producing granulocyte-macrophage--CSF ( GM-CSF). Thrombocytosis of greater than 400 x 10(9)/L was noted in 8 of 10 patients with G-CSF- producing tumors and all 4 patients with GM-CSF-producing tumors. Median peak platelet counts were, respectively, 511 x 10(9)/L (range, 384 to 694 x 10(9)/L) and 579 x 10(9)/L (range, 526 to 910 x 10(9)/L) in patients with tumors producing G-CSF and GM-CSF. In most patients, thrombocytosis declined towards the terminal stage. High interleukin-1 ( IL-1) and IL-6 levels were found in addition to CSFs in the plasma or culture supernatants of tumor cells obtained from most patients. In patients with GM-CSF-producing tumors, these specimens had megakaryocyte- CSF (Meg- CSF) activity, which was abolished by anti- GM-CSF antibody. These specimens also had megakaryocyte potentiating (Meg-Pot) activity attributable to both GM-CSF and IL-6. In patients with G-CSF-producing tumors, only Meg-Pot activity due to IL-6 was detected. These results indicate that the thrombocytosis in GM-CSF- producing tumors was caused by both the Meg- CSF activity of GM-CSF and the Meg-Pot activity of IL-6 plus GM-CSF, while that in G-CSF- producing tumors was due to the Meg-Pot activity of IL-6.[1]References
- Thrombocytosis in patients with tumors producing colony-stimulating factor. Suzuki, A., Takahashi, T., Nakamura, K., Tsuyuoka, R., Okuno, Y., Enomoto, T., Fukumoto, M., Imura, H. Blood (1992) [Pubmed]
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