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Disease relevance of Megakaryocytes

  • Unexpectedly, NF-E2-/- mice lack circulating platelets and die of hemorrhage; their megakaryocytes show no cytoplasmic platelet formation [1].
  • Initial data suggest that megakaryocyte production is stimulated by a factor detectable in aplastic anemia serum that may be distinct from other known hematopoietic stem cell regulators [2].
  • VASP-/- mice demonstrated hyperplasia of megakaryocytes in bone marrow and spleen but exhibited no other macroscopic or microscopic abnormalities [3].
  • Preliminary biological characterization indicates that in addition to stimulating plasmacytoma proliferation, IL-11 stimulates the T-cell-dependent development of immunoglobulin-producing B cells and synergizes with IL-3 in supporting murine megakaryocyte colony formation [4].
  • Using the technique of thrombophoresis (TP), platelet and megakaryocyte dynamics following acute thrombocytopenia were studied in two normal subjects during periods of ethanol ingestion and abstinence [5].

Psychiatry related information on Megakaryocytes


High impact information on Megakaryocytes


Chemical compound and disease context of Megakaryocytes


Biological context of Megakaryocytes


Anatomical context of Megakaryocytes


Associations of Megakaryocytes with chemical compounds


Gene context of Megakaryocytes

  • One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocyte progenitors, and the second, thrombopoietin, is a megakaryocyte maturation factor [29].
  • This subunit of NF-E2 is specifically expressed in haematopoietic progenitor cells and differentiated cells of the erythroid, megakaryocyte and mast cell lineages [30].
  • The c-mpl-/- mice had an 85 percent decrease in their number of platelets and megakaryocytes but had normal amounts of other hematopoietic cell types [31].
  • Accordingly, absence of Tel/Etv6 after lineage commitment is ostensibly without consequence except for unexpected impairment of maturation of megakaryocytes [32].
  • Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation [33].

Analytical, diagnostic and therapeutic context of Megakaryocytes


  1. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Shivdasani, R.A., Rosenblatt, M.F., Zucker-Franklin, D., Jackson, C.W., Hunt, P., Saris, C.J., Orkin, S.H. Cell (1995) [Pubmed]
  2. Regulation of human megakaryocytopoiesis. An in vito analysis. Mazur, E.M., Hoffman, R., Bruno, E. J. Clin. Invest. (1981) [Pubmed]
  3. Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice. Hauser, W., Knobeloch, K.P., Eigenthaler, M., Gambaryan, S., Krenn, V., Geiger, J., Glazova, M., Rohde, E., Horak, I., Walter, U., Zimmer, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Paul, S.R., Bennett, F., Calvetti, J.A., Kelleher, K., Wood, C.R., O'Hara, R.M., Leary, A.C., Sibley, B., Clark, S.C., Williams, D.A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  5. Induction of thrombocytopenia by thrombopheresis in man: patterns of recovery in normal subjects during ethanol ingestion and abstinence. Sullivan, L.W., Adams, W.H., Liu, Y.K. Blood (1977) [Pubmed]
  6. NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation. Hashimoto, M., Yoshimoto, M., Sisk, A., Hsu, L.J., Sundsmo, M., Kittel, A., Saitoh, T., Miller, A., Masliah, E. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  7. The complex cartography of stem cell commitment. Akashi, K., Traver, D., Zon, L.I. Cell (2005) [Pubmed]
  8. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C.T., Bryder, D., Yang, L., Borge, O.J., Thoren, L.A., Anderson, K., Sitnicka, E., Sasaki, Y., Sigvardsson, M., Jacobsen, S.E. Cell (2005) [Pubmed]
  9. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Bartley, T.D., Bogenberger, J., Hunt, P., Li, Y.S., Lu, H.S., Martin, F., Chang, M.S., Samal, B., Nichol, J.L., Swift, S. Cell (1994) [Pubmed]
  10. Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. Fang, J., Hodivala-Dilke, K., Johnson, B.D., Du, L.M., Hynes, R.O., White, G.C., Wilcox, D.A. Blood (2005) [Pubmed]
  11. Platelet production after administration of antiplatelet serum and 5-fluorouracil. Radley, J.M., Hodgson, G.S., Levin, J. Blood (1980) [Pubmed]
  12. Sialic acid in mature megakaryocytes: detection by wheat germ agglutinin. Schick, P.K., Filmyer, W.G. Blood (1985) [Pubmed]
  13. Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma. Lonial, S., Waller, E.K., Richardson, P.G., Jagannath, S., Orlowski, R.Z., Giver, C.R., Jaye, D.L., Francis, D., Giusti, S., Torre, C., Barlogie, B., Berenson, J.R., Singhal, S., Schenkein, D.P., Esseltine, D.L., Anderson, J., Xiao, H., Heffner, L.T., Anderson, K.C. Blood (2005) [Pubmed]
  14. Macrothrombocytopenia with abnormal demarcation membranes in megakaryocytes and neutropenia with a complete lack of sialyl-Lewis-X antigen in leukocytes--a new syndrome? Willig, T.B., Breton-Gorius, J., Elbim, C., Mignotte, V., Kaplan, C., Mollicone, R., Pasquier, C., Filipe, A., Miélot, F., Cartron, J.P., Gougerot-Pocidalo, M.A., Debili, N., Guichard, J., Dommergues, J.P., Mohandas, N., Tchernia, G. Blood (2001) [Pubmed]
  15. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Kaushansky, K., Lok, S., Holly, R.D., Broudy, V.C., Lin, N., Bailey, M.C., Forstrom, J.W., Buddle, M.M., Oort, P.J., Hagen, F.S. Nature (1994) [Pubmed]
  16. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Ichikawa, M., Asai, T., Saito, T., Seo, S., Yamazaki, I., Yamagata, T., Mitani, K., Chiba, S., Ogawa, S., Kurokawa, M., Hirai, H. Nat. Med. (2004) [Pubmed]
  17. Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter. Tronik-Le Roux, D., Roullot, V., Schweitzer, A., Berthier, R., Marguerie, G. J. Exp. Med. (1995) [Pubmed]
  18. Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin. Grzegorzewski, K., Ruscetti, F.W., Usui, N., Damia, G., Longo, D.L., Carlino, J.A., Keller, J.R., Wiltrout, R.H. J. Exp. Med. (1994) [Pubmed]
  19. Recombinant murine granulocyte macrophage colony-stimulating factor has megakaryocyte colony-stimulating activity and augments megakaryocyte colony stimulation by interleukin 3. Robinson, B.E., McGrath, H.E., Quesenberry, P.J. J. Clin. Invest. (1987) [Pubmed]
  20. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Martin, D.I., Zon, L.I., Mutter, G., Orkin, S.H. Nature (1990) [Pubmed]
  21. Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor. Munker, R., Gasson, J., Ogawa, M., Koeffler, H.P. Nature (1986) [Pubmed]
  22. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Akashi, K., Traver, D., Miyamoto, T., Weissman, I.L. Nature (2000) [Pubmed]
  23. Structure of pre-pro-von Willebrand factor and its expression in heterologous cells. Bonthron, D.T., Handin, R.I., Kaufman, R.J., Wasley, L.C., Orr, E.C., Mitsock, L.M., Ewenstein, B., Loscalzo, J., Ginsburg, D., Orkin, S.H. Nature (1986) [Pubmed]
  24. Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol. Nagata, Y., Yoshikawa, J., Hashimoto, A., Yamamoto, M., Payne, A.H., Todokoro, K. Genes Dev. (2003) [Pubmed]
  25. Cytochemical localization of lysosomal enzymes in rat megakaryocytes and platelets. Bentfeld, M.E., Bainton, D.F. J. Clin. Invest. (1975) [Pubmed]
  26. Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules. Handagama, P., Bainton, D.F., Jacques, Y., Conn, M.T., Lazarus, R.A., Shuman, M.A. J. Clin. Invest. (1993) [Pubmed]
  27. Identification of intracellular factor XIII in human monocytes and macrophages. Henriksson, P., Becker, S., Lynch, G., McDonagh, J. J. Clin. Invest. (1985) [Pubmed]
  28. A role for 1,25-dihydroxyvitamin D3 in control of bone-marrow collagen deposition? McCarthy, D.M., Hibbin, J.A., Goldman, J.M. Lancet (1984) [Pubmed]
  29. cMpl ligand is a humoral regulator of megakaryocytopoiesis. Wendling, F., Maraskovsky, E., Debili, N., Florindo, C., Teepe, M., Titeux, M., Methia, N., Breton-Gorius, J., Cosman, D., Vainchenker, W. Nature (1994) [Pubmed]
  30. Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Peters, L.L., Andrews, N.C., Eicher, E.M., Davidson, M.B., Orkin, S.H., Lux, S.E. Nature (1993) [Pubmed]
  31. Thrombocytopenia in c-mpl-deficient mice. Gurney, A.L., Carver-Moore, K., de Sauvage, F.J., Moore, M.W. Science (1994) [Pubmed]
  32. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Hock, H., Meade, E., Medeiros, S., Schindler, J.W., Valk, P.J., Fujiwara, Y., Orkin, S.H. Genes Dev. (2004) [Pubmed]
  33. Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation. Hamada, T., Möhle, R., Hesselgesser, J., Hoxie, J., Nachman, R.L., Moore, M.A., Rafii, S. J. Exp. Med. (1998) [Pubmed]
  34. Human megakaryocytes. II. Expression of platelet proteins in early marrow megakaryocytes. Rabellino, E.M., Levene, R.B., Leung, L.L., Nachman, R.L. J. Exp. Med. (1981) [Pubmed]
  35. Multimerin is found in the alpha-granules of resting platelets and is synthesized by a megakaryocytic cell line. Hayward, C.P., Bainton, D.F., Smith, J.W., Horsewood, P., Stead, R.H., Podor, T.J., Warkentin, T.E., Kelton, J.G. J. Clin. Invest. (1993) [Pubmed]
  36. Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via btk in platelets and megakaryocytes without increasing phospholipase C activity. Pasquet, J.M., Quek, L., Stevens, C., Bobe, R., Huber, M., Duronio, V., Krystal, G., Watson, S.P. EMBO J. (2000) [Pubmed]
  37. Suppression of the delayed rectifier type of voltage gated K+ outward current in megakaryocytes from patients with myelogenous leukemias. Kapural, L., Feinstein, M.B., O'Rourke, F., Fein, A. Blood (1995) [Pubmed]
  38. The ski/sno protooncogene family in hematopoietic development. Pearson-White, S., Deacon, D., Crittenden, R., Brady, G., Iscove, N., Quesenberry, P.J. Blood (1995) [Pubmed]
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