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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Thrombocytosis


High impact information on Thrombocytosis


Chemical compound and disease context of Thrombocytosis


Biological context of Thrombocytosis


Anatomical context of Thrombocytosis


Gene context of Thrombocytosis

  • To gain insight into the mechanism by which 5-FU produces such a substantial stimulation of platelet production, this study investigated whether 5-FU (150 mg/kg) produced thrombocytosis in c-mpl(-/-) mice, thus establishing whether TPO was required for this response [23].
  • It is shown that IL-6-induced thrombocytosis in C57BL/10 mice is accompanied by enhanced hepatic TPO mRNA expression and elevated TPO plasma levels [15].
  • W/Wv mice, mutated at the locus encoding the SCF receptor, also do not undergo rebound thrombocytosis, but are not responsive to SCF treatment [10].
  • Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6 [24].
  • We investigated the cause of thrombocytosis in 14 patients with tumors producing colony-stimulating factor (CSF) [25].
  • We found that perturbation of lipid raft formation by statins decreases SDF-1/C3a-dependent platelet production in vitro and in an in vivo model statins ameliorated post-bleeding thrombocytosis [26].

Analytical, diagnostic and therapeutic context of Thrombocytosis


  1. Deficiency of platelet lipoxygenase activity in myeloproliferative disorders. Schafer, A.I. N. Engl. J. Med. (1982) [Pubmed]
  2. Analysis of platelets from patients with thrombocythemia for reverse transcriptase and virus-like particles. Brodsky, I., Fuscaldo, A.A., Erlick, B.J., Kingsbury, E.W., Schultz, G.M., Fuscaldo, K.E. J. Natl. Cancer Inst. (1975) [Pubmed]
  3. Thrombocytosis in Whipple's disease. Nuzum, C.T., Sandler, R.S., Paulk, H.T. Gastroenterology (1981) [Pubmed]
  4. Erythromelalgia caused by platelet-mediated arteriolar inflammation and thrombosis in thrombocythemia. Michiels, J.J., Abels, J., Steketee, J., van Vliet, H.H., Vuzevski, V.D. Ann. Intern. Med. (1985) [Pubmed]
  5. Intracellular growth factors in polycythemia vera and other myeloproliferative disorders. Eid, J., Ebert, R.F., Gesell, M.S., Spivak, J.L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  6. Hydroxyurea in essential thrombocytosis. Ring, T. N. Engl. J. Med. (1995) [Pubmed]
  7. Uracil mustard in the treatment of thrombocytosis. Shamasunder, H.K., Gregory, S.A., Knospe, W.H. JAMA (1980) [Pubmed]
  8. Thrombocytosis in patients with celiac sprue. Nelson, E.W., Ertan, A., Brooks, F.P., Cerda, J.J. Gastroenterology (1976) [Pubmed]
  9. Thrombocytosis associated with low-molecular-weight heparin. Williams, E. Ann. Intern. Med. (1997) [Pubmed]
  10. Evidence that stem cell factor is involved in the rebound thrombocytosis that follows 5-fluorouracil treatment. Hunt, P., Zsebo, K.M., Hokom, M.M., Hornkohl, A., Birkett, N.C., del Castillo, J.C., Martin, F. Blood (1992) [Pubmed]
  11. Cerebral and retinal vascular complications of inflammatory bowel disease. Schneiderman, J.H., Sharpe, J.A., Sutton, D.M. Ann. Neurol. (1979) [Pubmed]
  12. Protective effect of ICRF-187 against normal tissue injury induced by adriamycin in combination with whole body hyperthermia. Baba, H., Stephens, L.C., Strebel, F.R., Siddik, Z.H., Newman, R.A., Ohno, S., Bull, J.M. Cancer Res. (1991) [Pubmed]
  13. All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines. Authier, F.J., Belec, L., Levy, Y., Lefaucheur, J.P., Defer, G.L., Degos, J.D., Gherardi, R.K. Arthritis Rheum. (1996) [Pubmed]
  14. Case report of dapsone-related thrombocytosis in an AIDS patient. Wynn, R.F., Laing, R.B., Leen, C.L. Am. J. Med. (1995) [Pubmed]
  15. Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. Kaser, A., Brandacher, G., Steurer, W., Kaser, S., Offner, F.A., Zoller, H., Theurl, I., Widder, W., Molnar, C., Ludwiczek, O., Atkins, M.B., Mier, J.W., Tilg, H. Blood (2001) [Pubmed]
  16. Prolonged thrombocytosis in mice after 5-fluorouracil results from failure to down-regulate megakaryocyte concentration. An experimental model that dissociates regulation of megakaryocyte size and DNA content from megakaryocyte concentration. Chenaille, P.J., Steward, S.A., Ashmun, R.A., Jackson, C.W. Blood (1990) [Pubmed]
  17. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Ulich, T.R., del Castillo, J., Yin, S., Swift, S., Padilla, D., Senaldi, G., Bennett, L., Shutter, J., Bogenberger, J., Sun, D. Blood (1995) [Pubmed]
  18. Transient neurologic and ocular manifestations in primary thrombocythemia. Michiels, J.J., Koudstaal, P.J., Mulder, A.H., van Vliet, H.H. Neurology (1993) [Pubmed]
  19. Blast crisis accompanied with occurrence of the point-mutational activation of N-ras proto-oncogene and the chromosomal abnormality inv(3q) in chronic myelogenous leukemia presenting thrombocytosis. Okabe, M., Kunieda, Y., Saiki, I., Shikano, T., Kakinuma, M., Miyazaki, T. Leukemia (1990) [Pubmed]
  20. Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin. Liu, E., Jelinek, J., Pastore, Y.D., Guan, Y., Prchal, J.F., Prchal, J.T. Blood (2003) [Pubmed]
  21. Serum thrombopoietin level is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis. Nagata, Y., Shozaki, Y., Nagahisa, H., Nagasawa, T., Abe, T., Todokoro, K. Thromb. Haemost. (1997) [Pubmed]
  22. Patients with thrombocytosis have normal or slightly elevated thrombopoietin levels. Español, I., Hernández, A., Cortés, M., Mateo, J., Pujol-Moix, N. Haematologica (1999) [Pubmed]
  23. Thrombocytopenic c-mpl(-/-) mice can produce a normal level of platelets after administration of 5-fluorouracil: the effect of age on the response. Levin, J., Cocault, L., Demerens, C., Challier, C., Pauchard, M., Caen, J., Souyri, M. Blood (2001) [Pubmed]
  24. Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6. Kimura, H., Ishibashi, T., Shikama, Y., Okano, A., Akiyama, Y., Uchida, T., Maruyama, Y. Blood (1990) [Pubmed]
  25. Thrombocytosis in patients with tumors producing colony-stimulating factor. Suzuki, A., Takahashi, T., Nakamura, K., Tsuyuoka, R., Okuno, Y., Enomoto, T., Fukumoto, M., Imura, H. Blood (1992) [Pubmed]
  26. Cleavage fragments of the third complement component (C3) enhance stromal derived factor-1 (SDF-1)-mediated platelet production during reactive postbleeding thrombocytosis. Wysoczynski, M., Kucia, M., Ratajczak, J., Ratajczak, M.Z. Leukemia (2007) [Pubmed]
  27. Elevated plasma thrombopoietic activity in patients with metastatic cancer-related thrombocytosis. Estrov, Z., Talpaz, M., Mavligit, G., Pazdur, R., Harris, D., Greenberg, S.M., Kurzrock, R. Am. J. Med. (1995) [Pubmed]
  28. Ribavirin prophylaxis and therapy for experimental argentine hemorrhagic fever. McKee, K.T., Huggins, J.W., Trahan, C.J., Mahlandt, B.G. Antimicrob. Agents Chemother. (1988) [Pubmed]
  29. Manifestations of cancer cachexia induced by colon 26 adenocarcinoma are not fully ascribable to interleukin-6. Soda, K., Kawakami, M., Kashii, A., Miyata, M. Int. J. Cancer (1995) [Pubmed]
  30. Induction of megakaryocytic colony-stimulating activity in mouse skin by inflammatory agents and tumor promoters. Clark, D.A., Dessypris, E.N., Koury, M.J. Proc. Soc. Exp. Biol. Med. (1987) [Pubmed]
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