- Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester. Girotra, N.N., Biftu, T., Ponpipom, M.M., Acton, J.J., Alberts, A.W., Bach, T.N., Ball, R.G., Bugianesi, R.L., Parsons, W.H., Chabala, J.C. J. Med. Chem. (1992)