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Chemical Compound Review

BSPBio_001448     2-[[(2R)-2-acetyloxy-3- hexadecoxy-propoxy]...

Synonyms: KBioGR_000168, KBioSS_000168, CBiol_001755, LS-187258, KBio2_000168, ...
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Disease relevance of PAF acether

  • The data indicate that TNF induces neutrophil-dependent pulmonary edema associated with increased Ppc (mediated by TXA2 and PAF), increased Kf,c (mediated by PAF), and changes in endothelial peripheral actin bands [1].
  • Thus, it appears that TNF release alone, without a sufficient increase in PAF, is incapable of causing severe hypotension [2].
  • In man, inhalation of PAF causes a bronchospasm and induces a bronchial hyperreactivity [3].
  • Among the mediators involved in the pathophysiologic mechanisms that underly the reactions of the acute and delayed phases of bronchospasm induced by allergens in man, platelet-activating factor (PAF) could play an important role, in particular by its effects on platelets [3].
  • In addition, Langendorff-perfused PI3Kgamma-null hearts showed a better contractile recovery after ischemia/reperfusion, a condition where PAF is known to be an important player in depressing contractility [4].

High impact information on PAF acether

  • These results demonstrate that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent [5].
  • We demonstrated that human endothelial cells synthesize two vasoactive lipids, platelet-activating factor (PAF) and prostacyclin, in response to alpha toxin treatment [6].
  • Similar results were observed in neutrophils activated with platelet-activating factor (PAF) [7].
  • Hly provoked rapid secretion of elastase and myeloperoxidase, generation of superoxide, and synthesis of platelet-activating factor (PAF) and lyso-PAF [8].
  • E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils [9].

Chemical compound and disease context of PAF acether


Biological context of PAF acether


Anatomical context of PAF acether

  • Here, the biological activities and the activation profile of Eotaxin were further characterized and compared with those of other eosinophil chemotaxins such as complement fragment C5a (C5a), platelet-activating factor (PAF), and RANTES in human eosinophils [16].
  • In this study, we determined which mediator from cutaneous mast cells mediates substance P-induced granulocyte infiltration in the skin by the use of two mediator antagonists; one for platelet activating factor (PAF) CV-6209 and the other for leukotriene B4 (LTB4) ONO-4057 [17].
  • We assessed the adrenergic-receptor system in individuals with bronchial hyperreactivity, beta-Adrenergic receptors on mononuclear cell membranes, alpha-adrenergic receptors on platelet membranes, and the cAMP response in these cell types to different stimuli, including platelet-activating factor (PAF), were determined [18].
  • The levels of L-myo-[3H]inositol 1,4,5,6-tetrakisphosphate in primary-cultured macrophages are not acutely sensitive to PAF [19].
  • The migration of anti-CD18 mAb-treated PMNLs was not inhibited by function-blocking mAbs to sialyl Lewisx, L-selectin, beta 1 or alpha 4 integrin, the beta 3-related leukocyte response integrin, IL-8, or platelet-activating factor (PAF) antagonists, alone or in combination [20].

Associations of PAF acether with other chemical compounds


Gene context of PAF acether


Analytical, diagnostic and therapeutic context of PAF acether


  1. Mechanisms of pulmonary edema induced by tumor necrosis factor-alpha. Hocking, D.C., Phillips, P.G., Ferro, T.J., Johnson, A. Circ. Res. (1990) [Pubmed]
  2. Effects of in vivo 'priming' on endotoxin-induced hypotension and tissue injury. The role of PAF and tumor necrosis factor. Sun, X.M., Hsueh, W., Torre-Amione, G. Am. J. Pathol. (1990) [Pubmed]
  3. Platelet function: aggregation by PAF or sequestration in lung is not modified during immediate or late allergen-induced bronchospasm in man. Hemmendinger, S., Pauli, G., Tenabene, A., Pujol, J.L., Bessot, J.C., Eber, M., Cazenave, J.P. J. Allergy Clin. Immunol. (1989) [Pubmed]
  4. Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. Alloatti, G., Levi, R., Malan, D., Del Sorbo, L., Bosco, O., Barberis, L., Marcantoni, A., Bedendi, I., Penna, C., Azzolino, O., Altruda, F., Wymann, M., Hirsch, E., Montrucchio, G. Cardiovasc. Res. (2003) [Pubmed]
  5. Mast cells are required for experimental oral allergen-induced diarrhea. Brandt, E.B., Strait, R.T., Hershko, D., Wang, Q., Muntel, E.E., Scribner, T.A., Zimmermann, N., Finkelman, F.D., Rothenberg, M.E. J. Clin. Invest. (2003) [Pubmed]
  6. Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells. Bunting, M., Lorant, D.E., Bryant, A.E., Zimmerman, G.A., McIntyre, T.M., Stevens, D.L., Prescott, S.M. J. Clin. Invest. (1997) [Pubmed]
  7. Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. Sperling, R.I., Benincaso, A.I., Knoell, C.T., Larkin, J.K., Austen, K.F., Robinson, D.R. J. Clin. Invest. (1993) [Pubmed]
  8. Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils. Grimminger, F., Sibelius, U., Bhakdi, S., Suttorp, N., Seeger, W. J. Clin. Invest. (1991) [Pubmed]
  9. E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils. McMeekin, S.R., Dransfield, I., Rossi, A.G., Haslett, C., Walker, T.R. Blood (2006) [Pubmed]
  10. Oxygen-dependent PAF receptor binding and intracellular signaling in ovine fetal pulmonary vascular smooth muscle. Ibe, B.O., Portugal, A.M., Chaturvedi, S., Raj, J.U. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  11. Effects of PAF antagonist, BN52021, on the PAF-, methacholine-, and allergen-induced bronchoconstriction in asthmatic children. Hsieh, K.H. Chest (1991) [Pubmed]
  12. Control of local blood flow in pulmonary inflammation: role for neutrophils, PAF, and thromboxane. Hellewell, P.G., Henson, P.M., Downey, G.P., Worthen, G.S. J. Appl. Physiol. (1991) [Pubmed]
  13. No increase in plasma histamine during PAF-induced airway obstruction in allergic asthmatics. Louis, R., Bury, T., Corhay, J.L., Radermecker, M. Chest (1993) [Pubmed]
  14. Regulation of glycoprotein IIB/IIIA exposure on platelets stimulated with alpha-thrombin. van Willigen, G., Akkerman, J.W. Blood (1992) [Pubmed]
  15. Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. Brown, G.E., Stewart, M.Q., Bissonnette, S.A., Elia, A.E., Wilker, E., Yaffe, M.B. J. Biol. Chem. (2004) [Pubmed]
  16. Recombinant human eotaxin induces oxygen radical production, Ca(2+)-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein. Tenscher, K., Metzner, B., Schöpf, E., Norgauer, J., Czech, W. Blood (1996) [Pubmed]
  17. Leukotriene B4 mediates substance P-induced granulocyte infiltration into mouse skin. Comparison with antigen-induced granulocyte infiltration. Iwamoto, I., Tomoe, S., Tomioka, H., Yoshida, S. J. Immunol. (1993) [Pubmed]
  18. Alpha- and beta-adrenergic-receptor systems in bronchial asthma and in subjects without asthma: reduced mononuclear cell beta-receptors in bronchial asthma. Sato, T., Bewtra, A.K., Hopp, R.J., Nair, N., Townley, R.G. J. Allergy Clin. Immunol. (1990) [Pubmed]
  19. L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells. Stephens, L., Hawkins, P.T., Carter, N., Chahwala, S.B., Morris, A.J., Whetton, A.D., Downes, P.C. Biochem. J. (1988) [Pubmed]
  20. CD11/CD18-independent transendothelial migration of human polymorphonuclear leukocytes and monocytes: involvement of distinct and unique mechanisms. Issekutz, A.C., Chuluyan, H.E., Lopes, N. J. Leukoc. Biol. (1995) [Pubmed]
  21. Pharmacokinetics and pharmacodynamics of neutrophil-associated ciprofloxacin in humans. Capecchi, P.L., Blardi, P., De Lalla, A., Ceccatelli, L., Volpi, L., Pasini, L., Di Perri, T. Clin. Pharmacol. Ther. (1995) [Pubmed]
  22. VEGF-mediated endothelial P-selectin translocation: role of VEGF receptors and endogenous PAF synthesis. Rollin, S., Lemieux, C., Maliba, R., Favier, J., Villeneuve, L.R., Allen, B.G., Soker, S., Bazan, N.G., Merhi, Y., Sirois, M.G. Blood (2004) [Pubmed]
  23. Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. Chen, L.W., Huang, H.L., Lee, I.T., Hsu, C.M., Lu, P.J. Shock (2006) [Pubmed]
  24. Integrin alpha 4 beta 7 mediates human eosinophil interaction with MAdCAM-1, VCAM-1 and fibronectin. Walsh, G.M., Symon, F.A., Lazarovils, A.L., Wardlaw, A.J. Immunology (1996) [Pubmed]
  25. The monocyte chemotactic protein-4 induces oxygen radical production, actin reorganization, and CD11b up-regulation via a pertussis toxin-sensitive G-protein in human eosinophils. Tenscher, K., Metzner, B., Hofmann, C., Schöpf, E., Norgauer, J. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  26. Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells. Hidalgo, M.A., Romero, A., Figueroa, J., Cortés, P., Concha, I.I., Hancke, J.L., Burgos, R.A. Br. J. Pharmacol. (2005) [Pubmed]
  27. Prevention of non-specific airway hyperreactivity after allergen challenge in guinea-pigs by the PAF receptor antagonist SDZ 64-412. Havill, A.M., Van Valen, R.G., Handley, D.A. Br. J. Pharmacol. (1990) [Pubmed]
  28. Contributions of thromboxane and leukotrienes to PAF-induced impairment of lung function in the rat. Uhlig, S., Wollin, L., Wendel, A. J. Appl. Physiol. (1994) [Pubmed]
  29. Glycosylation enhances oxygen radical-induced modifications and decreases acetylhydrolase activity of human low density lipoprotein. Napoli, C., Triggiani, M., Palumbo, G., Condorelli, M., Chiariello, M., Ambrosio, G. Basic Res. Cardiol. (1997) [Pubmed]
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