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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Expression of neurofibromin, the neurofibromatosis 1 gene product: studies in human neuroblastoma cells and rat brain.

Neurofibromatosis type 1 (NF1) is one of the most frequent Mendelian disorders in man and one of the most common autosomal dominant disorders affecting the nervous system. The NF1 gene has recently been cloned, and shows homology to the GTPase activating protein. In order to characterize the NF1 gene product, now called neurofibromin, we raised polyclonal antibodies against C- and N-terminal regions of neurofibromin and analyzed the protein by Western blot analysis and immunohistochemical studies of rat brain.[1]

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