The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Nf1  -  neurofibromin 1

Rattus norvegicus

Synonyms: Neurofibromatosis-related protein NF-1, Neurofibromin
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Nf1


High impact information on Nf1


Chemical compound and disease context of Nf1


Biological context of Nf1

  • INTRODUCTION: Neurofibromatosis type 1 is caused by mutations in the NF1 gene encoding the Ras GTPase activating protein (Ras-GAP) neurofibromin [11].
  • These symptoms are congenital, implying a role for neurofibromin in proper bone growth [11].
  • Neurofibromin, the protein product of the Nf1 gene, is believed to act as a tumor suppressor, accelerating the conversion of the oncogene Ras to its inactive form [2].
  • Thus a G(1) phase-specific protein, cyclin D1, accounts for two salient features of Schwann cell growth control: the promitotic response to cAMP and the antimitotic response to the Nf1 tumor suppressor [12].
  • One cosmid probe, c11-1F10, demonstrated that both translocation breakpoints, and presumably NF1, are contained within a 600-kilobase Nru I fragment [7].

Anatomical context of Nf1


Associations of Nf1 with chemical compounds


Regulatory relationships of Nf1


Other interactions of Nf1


Analytical, diagnostic and therapeutic context of Nf1


  1. Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas. Krasnoselsky, A., Massay, M.J., DeFrances, M.C., Michalopoulos, G., Zarnegar, R., Ratner, N. J. Neurosci. (1994) [Pubmed]
  2. Expression of Kit in neurofibromin-deficient human Schwann cells: role in Schwann cell hyperplasia associated with type 1 neurofibromatosis. Badache, A., Muja, N., De Vries, G.H. Oncogene (1998) [Pubmed]
  3. Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB. Badache, A., De Vries, G.H. J. Cell. Physiol. (1998) [Pubmed]
  4. Regulation of neurofibromin expression in rat sciatic nerve and cultured Schwann cells. Wrabetz, L., Feltri, M.L., Kim, H., Daston, M., Kamholz, J., Scherer, S.S., Ratner, N. Glia (1995) [Pubmed]
  5. Somatic mutations in the neurofibromatosis 1 gene in human tumors. Li, Y., Bollag, G., Clark, R., Stevens, J., Conroy, L., Fults, D., Ward, K., Friedman, E., Samowitz, W., Robertson, M. Cell (1992) [Pubmed]
  6. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Basu, T.N., Gutmann, D.H., Fletcher, J.A., Glover, T.W., Collins, F.S., Downward, J. Nature (1992) [Pubmed]
  7. Two NF1 translocations map within a 600-kilobase segment of 17q11.2. O'Connell, P., Leach, R., Cawthon, R.M., Culver, M., Stevens, J., Viskochil, D., Fournier, R.E., Rich, D.C., Ledbetter, D.H., White, R. Science (1989) [Pubmed]
  8. The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes. Daston, M.M., Scrable, H., Nordlund, M., Sturbaum, A.K., Nissen, L.M., Ratner, N. Neuron (1992) [Pubmed]
  9. Merlin, the neurofibromatosis type 2 gene product, and beta1 integrin associate in isolated and differentiating Schwann cells. Obremski, V.J., Hall, A.M., Fernandez-Valle, C. J. Neurobiol. (1998) [Pubmed]
  10. Chromaffin cells as models of endocrine cells and neurons. Tischler, A.S. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  11. NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos. Kuorilehto, T., Nissinen, M., Koivunen, J., Benson, M.D., Peltonen, J. J. Bone Miner. Res. (2004) [Pubmed]
  12. Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. Kim, H.A., Ratner, N., Roberts, T.M., Stiles, C.D. J. Neurosci. (2001) [Pubmed]
  13. Fine structure DNA mapping studies of the chromosomal region harboring the genetic defect in neurofibromatosis type I. O'Connell, P., Leach, R.J., Ledbetter, D.H., Cawthon, R.M., Culver, M., Eldridge, J.R., Frej, A.K., Holm, T.R., Wolff, E., Thayer, M.J. Am. J. Hum. Genet. (1989) [Pubmed]
  14. Neurofibromin is enriched in the endoplasmic reticulum of CNS neurons. Nordlund, M., Gu, X., Shipley, M.T., Ratner, N. J. Neurosci. (1993) [Pubmed]
  15. Early lesion of N-nitroso-N-ethylurea-induced hamster neurofibromatosis model. Nakamura, T., Hara, M., Kasuga, T. Cancer Res. (1991) [Pubmed]
  16. Differences in the interaction of p21c-Ha-ras-GMP-PNP with full-length neurofibromin and GTPase-activating protein. DiBattiste, D., Golubic, M., Stacey, D., Wolfman, A. Oncogene (1993) [Pubmed]
  17. cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion. Brooks, H.L., Ageloff, S., Kwon, T.H., Brandt, W., Terris, J.M., Seth, A., Michea, L., Nielsen, S., Fenton, R., Knepper, M.A. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  18. Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin. Meng, J.J., Lowrie, D.J., Sun, H., Dorsey, E., Pelton, P.D., Bashour, A.M., Groden, J., Ratner, N., Ip, W. J. Neurosci. Res. (2000) [Pubmed]
  19. Different structural requirements within the switch II region of the Ras protein for interactions with specific downstream targets. Moodie, S.A., Paris, M., Villafranca, E., Kirshmeier, P., Willumsen, B.M., Wolfman, A. Oncogene (1995) [Pubmed]
  20. NF1 mRNA isoform expression in PC12 cells: modulation by extrinsic factors. Metheny, L.J., Skuse, G.R. Exp. Cell Res. (1996) [Pubmed]
  21. Modulation of the neurofibromatosis type 1 gene product, neurofibromin, during Schwann cell differentiation. Gutmann, D.H., Tennekoon, G.I., Cole, J.L., Collins, F.S., Rutkowski, J.L. J. Neurosci. Res. (1993) [Pubmed]
  22. Expression of the neurofibromatosis I gene product, neurofibromin, in blood vessel endothelial cells and smooth muscle. Norton, K.K., Xu, J., Gutmann, D.H. Neurobiol. Dis. (1995) [Pubmed]
  23. Expression of the neurofibromatosis 1 (NF1) isoforms in developing and adult rat tissues. Gutmann, D.H., Geist, R.T., Wright, D.E., Snider, W.D. Cell Growth Differ. (1995) [Pubmed]
WikiGenes - Universities