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Korolenko, T.A. et al.

Korolenko, Poteryaeva, Falameeva, Levina,

Cystein proteinase inhibitor stefin A as an indicator of efficiency of tumor treatment in mice.

The concentration of stefin A (cystatin A in mice) was measured in animals with experimental tumors (LS lymphosarcoma, HA-1-hepatoma, and Lewis lung carcinoma) during effective antitumor therapy. In mice with these tumors serum concentrations of stefin A increased, while the concentration of cystatin C (extracellular cystein proteinase inhibitor) decreased. The concentration of stefin A in tumor tissue in Lewis lung carcinoma was higher than in LS lymphosarcoma and HA-1-hepatoma ascitic cells, which can be explained by the degree of their malignancy. The content of stefin A in tumor tissue was similar to that in the liver and spleen of tumor-bearing animals, while its concentration in the liver and spleen of tumor-bearing animals was lower than in intact mice. The level of stefin A is an important marker of malignancy and an indicator of the efficiency of antitumor therapy.[1]

References

Cystein proteinase inhibitor stefin A as an indicator of efficiency of tumor treatment in mice. Korolenko, T.A., Poteryaeva, O.N., Falameeva, O.V., Levina, O.A. Bull. Exp. Biol. Med. (2003) [Pubmed]

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