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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Gcn4 negatively regulates expression of genes subjected to nitrogen catabolite repression.

It has been considered that three key elements participate in nitrogen catabolite repression (NCR) of Saccharomyces cerevisiae: the GLN3 and GAT1/NIL1- encoded transcriptional activators and their negative regulator Ure2. The fact that expression of various NCR-sensitive genes is not derepressed in the absence of Ure2 has led to the proposition that there must exist a protein with a similar function to that of Ure2. The results presented in this paper show that various NCR-sensitive genes are derepressed through GLN3-mediated transcriptional activation in a gcn4Delta mutant. This effect is additive to that exerted by the lack of Ure2 and to that evoked in rapamycin-treated cultures. Our results uncover the fact that NCR is not solely achieved through the action of Gln3, Gat1, and Ure2. Since Gcn4 regulates the expression of a broad spectrum of genes, the lack of this transcriptional activator could prevent the expression of a potential Gln3 antagonist. Alternatively, Gcn4 could directly hinder Gln3 functioning.[1]


  1. Gcn4 negatively regulates expression of genes subjected to nitrogen catabolite repression. Sosa, E., Aranda, C., Riego, L., Valenzuela, L., DeLuna, A., Cantú, J.M., González, A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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