Gene Review:
GCN4 - Gcn4p
Saccharomyces cerevisiae S288c
Synonyms:
AAS101, AAS3, ARG9, Amino acid biosynthesis regulatory protein, General control protein GCN4, ...
- GCN4 protein, a positive transcription factor in yeast, binds general control promoters at all 5' TGACTC 3' sequences. Arndt, K., Fink, G.R. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Artificial oncoproteins: modified versions of the yeast bZip protein GCN4 induce cellular transformation. Nishizawa, M., Fu, S.L., Kataoka, K., Vogt, P.K. Oncogene (2003)
- DNA-mediated assembly of weakly interacting DNA-binding protein subunits: in vitro recruitment of phage 434 repressor and yeast GCN4 DNA-binding domains. Guarnaccia, C., Raman, B., Zahariev, S., Simoncsits, A., Pongor, S. Nucleic Acids Res. (2004)
- The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous. Struhl, K. Cell (1987)
- The cross-pathway control gene of Neurospora crassa, cpc-1, encodes a protein similar to GCN4 of yeast and the DNA-binding domain of the oncogene v-jun-encoded protein. Paluh, J.L., Orbach, M.J., Legerton, T.L., Yanofsky, C. Proc. Natl. Acad. Sci. U.S.A. (1988)
- The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Engelberg, D., Klein, C., Martinetto, H., Struhl, K., Karin, M. Cell (1994)
- The acidic activation domains of the GCN4 and GAL4 proteins are not alpha helical but form beta sheets. Van Hoy, M., Leuther, K.K., Kodadek, T., Johnston, S.A. Cell (1993)
- Identification of three residues in the basic regions of the bZIP proteins GCN4, C/EBP and TAF-1 that are involved in specific DNA binding. Suckow, M., von Wilcken-Bergmann, B., Müller-Hill, B. EMBO J. (1993)
- Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. Futaki, S., Suzuki, T., Ohashi, W., Yagami, T., Tanaka, S., Ueda, K., Sugiura, Y. J. Biol. Chem. (2001)
- PvAlf, an embryo-specific acidic transcriptional activator enhances gene expression from phaseolin and phytohemagglutinin promoters. Bobb, A.J., Eiben, H.G., Bustos, M.M. Plant J. (1995)
- Multiple global regulators control HIS4 transcription in yeast. Arndt, K.T., Styles, C., Fink, G.R. Science (1987)
- Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA. Williams, N.P., Hinnebusch, A.G., Donahue, T.F. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2. Rolfes, R.J., Hinnebusch, A.G. Mol. Cell. Biol. (1993)
- Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Ramirez, M., Wek, R.C., Vazquez de Aldana, C.R., Jackson, B.M., Freeman, B., Hinnebusch, A.G. Mol. Cell. Biol. (1992)
- Heterologous expression of membrane and soluble proteins derepresses GCN4 mRNA translation in the yeast Saccharomyces cerevisiae. Steffensen, L., Pedersen, P.A. Eukaryotic Cell (2006)
- Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase. Yang, R., Wek, S.A., Wek, R.C. Mol. Cell. Biol. (2000)
- Translational activation of GCN4 mRNA in a cell-free system is triggered by uncharged tRNAs. Krupitza, G., Thireos, G. Mol. Cell. Biol. (1990)
- Study of translational control of eukaryotic gene expression using yeast. Hinnebusch, A.G., Asano, K., Olsen, D.S., Phan, L., Nielsen, K.H., Valásek, L. Ann. N. Y. Acad. Sci. (2004)
- A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast. Cigan, A.M., Bushman, J.L., Boal, T.R., Hinnebusch, A.G. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Arginine restriction induced by delta-N-(phosphonacetyl)-L-ornithine signals increased expression of HIS3, TRP5, CPA1, and CPA2 in Saccharomyces cerevisiae. Kinney, D.M., Lusty, C.J. Mol. Cell. Biol. (1989)
- Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae. Moehle, C.M., Hinnebusch, A.G. Mol. Cell. Biol. (1991)
- Activation and repression of the yeast ARO3 gene by global transcription factors. Künzler, M., Springer, C., Braus, G.H. Mol. Microbiol. (1995)
- Transcription factor GCN4 for control of amino acid biosynthesis also regulates the expression of the gene for lipoamide dehydrogenase. Zaman, Z., Bowman, S.B., Kornfeld, G.D., Brown, A.J., Dawes, I.W. Biochem. J. (1999)
- The general control activator protein GCN4 is essential for a basal level of ARO3 gene expression in Saccharomyces cerevisiae. Paravicini, G., Mösch, H.U., Schmidheini, T., Braus, G. Mol. Cell. Biol. (1989)
- Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Qiu, H., Hu, C., Anderson, J., Björk, G.R., Sarkar, S., Hopper, A.K., Hinnebusch, A.G. Mol. Cell. Biol. (2000)
- Global histone acetylation and deacetylation in yeast. Vogelauer, M., Wu, J., Suka, N., Grunstein, M. Nature (2000)
- Molecular analysis of GCN3, a translational activator of GCN4: evidence for posttranslational control of GCN3 regulatory function. Hannig, E.M., Hinnebusch, A.G. Mol. Cell. Biol. (1988)
- GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast. Hope, I.A., Struhl, K. Cell (1985)
- A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Hinnebusch, A.G. Mol. Cell. Biol. (1985)
- Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Bushman, J.L., Asuru, A.I., Matts, R.L., Hinnebusch, A.G. Mol. Cell. Biol. (1993)
- Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis. Dorris, D.R., Erickson, F.L., Hannig, E.M. EMBO J. (1995)
- ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance. Kanazawa, S., Driscoll, M., Struhl, K. Mol. Cell. Biol. (1988)
- Negative regulatory gene for general control of amino acid biosynthesis in Saccharomyces cerevisiae. Myers, P.L., Skvirsky, R.C., Greenberg, M.L., Greer, H. Mol. Cell. Biol. (1986)
- Transcriptional regulation of the one-carbon metabolism regulon in Saccharomyces cerevisiae by Bas1p. Subramanian, M., Qiao, W.B., Khanam, N., Wilkins, O., Der, S.D., Lalich, J.D., Bognar, A.L. Mol. Microbiol. (2005)
- Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Hope, I.A., Struhl, K. Cell (1986)
- Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA. Weiss, M.A., Ellenberger, T., Wobbe, C.R., Lee, J.P., Harrison, S.C., Struhl, K. Nature (1990)
- A flexible domain is essential for the large step size and processivity of myosin VI. Rock, R.S., Ramamurthy, B., Dunn, A.R., Beccafico, S., Rami, B.R., Morris, C., Spink, B.J., Franzini-Armstrong, C., Spudich, J.A., Sweeney, H.L. Mol. Cell (2005)