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Komatsuda, A. et al.

Komatsuda, Wakui, Ohtani, Maki, Nimura, Takatsu, Yamaguchi, Imai, Sawada,

Amyloid A-type renal amyloidosis in a patient with sarcoidosis: report of a case and review of the literature.

A 53-year-old man developed chronic renal failure during a protracted course of sarcoidosis. A renal biopsy showed Congo red-positive homogenous deposits in the subendothelial space of glomerular capillary walls and arterial walls. On electron microscopy, amyloid fibrils were observed in the deposits. Immunohistochemistry showed positive staining for amyloid A ( AA) protein. Treatment with prednisolone resulted in poor response, followed by progressive deterioration of renal function requiring hemodialysis. To our knowledge, there are 5 cases with histologically proven renal amyloidosis accompanied by sarcoidosis. Prognosis in these patients is extremely poor. AA-type amyloidosis should be considered as a rare renal complication in the setting of long-standing sarcoidosis.[1]

References

Amyloid A-type renal amyloidosis in a patient with sarcoidosis: report of a case and review of the literature. Komatsuda, A., Wakui, H., Ohtani, H., Maki, N., Nimura, T., Takatsu, H., Yamaguchi, A., Imai, H., Sawada, K. Clin. Nephrol. (2003) [Pubmed]

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