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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine.

This was a randomized, double-blind study designed to evaluate the comparative efficacy and tolerability of the 40-mg dose of eletriptan and the 2.5-mg dose of naratriptan. Patients (n = 548) meeting International Headache Society (IHS) criteria for migraine were randomized to treat a single migraine attack with either eletriptan 40 mg, naratriptan 2.5 mg, or placebo. Headache response rates at 2 h and 4 h, respectively, were 56% and 80% for eletriptan, 42% and 67% for naratriptan (P < 0.01 for both time-points vs. eletriptan), and 31% and 44% for placebo (P < 0.0001 vs. both active drugs at both time-points). Eletriptan also showed a significantly greater pain-free response at 2 h (35% vs. 18%; P < 0.001) as well as lower use of rescue medication (15% vs. 27%; P < 0.01) and higher sustained headache response at 24 h (38%) compared with naratriptan (27%; P < 0.05) and placebo (19%; P < 0.01). Both eletriptan and naratriptan were well tolerated. The results confirm previous meta-analyses that have suggested the superiority of eletriptan vs. naratriptan in the acute treatment of migraine.[1]


  1. Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine. Garcia-Ramos, G., MacGregor, E.A., Hilliard, B., Bordini, C.A., Leston, J., Hettiarachchi, J. Cephalalgia : an international journal of headache. (2003) [Pubmed]
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