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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

S100C/ A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes.

An increase in extracellular Ca2+ induces growth arrest and differentiation of human keratinocytes in culture. We examined possible involvement of S100C/ A11 in this growth regulation. On exposure of the cells to high Ca2+, S100C/ A11 was specifically phosphorylated at 10Thr and 94Ser. Phosphorylation facilitated the binding of S100C/ A11 to nucleolin, resulting in nuclear translocation of S100C/ A11. In nuclei, S100C/ A11 liberated Sp1/3 from nucleolin. The resulting free Sp1/3 transcriptionally activated p21CIP1/WAF1, a representative negative regulator of cell growth. Introduction of anti-S100C/ A11 antibody into the cells largely abolished the growth inhibition induced by Ca2+ and the induction of p21CIP1/WAF1. In the human epidermis, S100C/ A11 was detected in nuclei of differentiating cells in the suprabasal layers, but not in nuclei of proliferating cells in the basal layer. These results indicate that S100C/ A11 is a key mediator of the Ca(2+)-induced growth inhibition of human keratinocytes in culture, and that it may be possibly involved in the growth regulation in vivo as well.[1]


  1. S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes. Sakaguchi, M., Miyazaki, M., Takaishi, M., Sakaguchi, Y., Makino, E., Kataoka, N., Yamada, H., Namba, M., Huh, N.H. J. Cell Biol. (2003) [Pubmed]
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