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Gene Review

S100A11  -  S100 calcium binding protein A11

Homo sapiens

Synonyms: Calgizzarin, HEL-S-43, MLN 70, MLN70, Metastatic lymph node gene 70 protein, ...
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Disease relevance of S100A11


High impact information on S100A11


Chemical compound and disease context of S100A11


Biological context of S100A11


Anatomical context of S100A11


Associations of S100A11 with chemical compounds

  • Isoproterenol-induced myocardial injury resulting in altered S100A4 and S100A11 protein expression in the rat [13].
  • Elevation of the cytosolic Ca(2+) concentration by means of the Ca(2+) ionophore, ionomycin, caused a significant fraction of S100A11 to associate with vimentin intermediate filament (IF)-bound S100B, another member of the S100 protein family [14].
  • The application of thapsigargin, an agent increasing intracellular Ca(2+) levels, resulted in the relocation of the S100A11 [15].
  • Since translocation was not affected by treatment with brefeldin A, it appears that S100A11 relocates in an endoplasmic reticulum-Golgi-independent pathway [15].
  • The ability of S100A11 to form multimers indicates that it also has a reactive lysine residue that functions as an amine donor [16].

Physical interactions of S100A11


Regulatory relationships of S100A11


Other interactions of S100A11

  • S100A7 and S100A11 are present in the basal and spinous layers in normal epidermis [17].
  • Comparison of the differentially expressed genes with DNA copy number changes in Karpas299 revealed that two overexpressed genes, S100A10 and S100A11, were located in an amplicon suggesting that the increased mRNA levels were caused by DNA amplification [18].
  • In control cells, S100A11 was detected on the plasma membrane, where the protein co-localized with annexin I (ANXA1) at discrete sites, and found diffusely in the cytoplasm [14].
  • Involvement of interferon regulatory factor 1 and S100C/A11 in growth inhibition by transforming growth factor beta 1 in human hepatocellular carcinoma cells [19].
  • When a recombinant S100C/A11 protein was introduced into nuclei of JHH-5 cells, DNA synthesis was markedly inhibited in a dose-dependent manner in the absence of TGF-beta 1 [19].

Analytical, diagnostic and therapeutic context of S100A11


  1. S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. Deloulme, J.C., Assard, N., Mbele, G.O., Mangin, C., Kuwano, R., Baudier, J. J. Biol. Chem. (2000) [Pubmed]
  2. Increased expression of calcium-binding protein S100 in human uterine smooth muscle tumours. Kanamori, T., Takakura, K., Mandai, M., Kariya, M., Fukuhara, K., Sakaguchi, M., Huh, N.H., Saito, K., Sakurai, T., Fujita, J., Fujii, S. Mol. Hum. Reprod. (2004) [Pubmed]
  3. Human S100A11 exhibits differential steady-state RNA levels in various tissues and a distinct subcellular localization. Inada, H., Naka, M., Tanaka, T., Davey, G.E., Heizmann, C.W. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  4. Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products. Cecil, D.L., Johnson, K., Rediske, J., Lotz, M., Schmidt, A.M., Terkeltaub, R. J. Immunol. (2005) [Pubmed]
  5. S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer. Mori, M., Shimada, H., Gunji, Y., Matsubara, H., Hayashi, H., Nimura, Y., Kato, M., Takiguchi, M., Ochiai, T., Seki, N. Oncol. Rep. (2004) [Pubmed]
  6. Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes. Cecil, D.L., Terkeltaub, R. J. Immunol. (2008) [Pubmed]
  7. PKCalpha mediates TGFbeta-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11. Sakaguchi, M., Miyazaki, M., Sonegawa, H., Kashiwagi, M., Ohba, M., Kuroki, T., Namba, M., Huh, N.H. J. Cell Biol. (2004) [Pubmed]
  8. S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes. Sakaguchi, M., Miyazaki, M., Takaishi, M., Sakaguchi, Y., Makino, E., Kataoka, N., Yamada, H., Namba, M., Huh, N.H. J. Cell Biol. (2003) [Pubmed]
  9. Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts. Sakaguchi, M., Miyazaki, M., Inoue, Y., Tsuji, T., Kouchi, H., Tanaka, T., Yamada, H., Namba, M. J. Cell Biol. (2000) [Pubmed]
  10. Dysregulated expression of S100A11 (calgizzarin) in prostate cancer and precursor lesions. Rehman, I., Azzouzi, A.R., Cross, S.S., Deloulme, J.C., Catto, J.W., Wylde, N., Larre, S., Champigneuille, J., Hamdy, F.C. Hum. Pathol. (2004) [Pubmed]
  11. Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I. Réty, S., Osterloh, D., Arié, J.P., Tabaries, S., Seeman, J., Russo-Marie, F., Gerke, V., Lewit-Bentley, A. Structure (2000) [Pubmed]
  12. Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor. Broome, A.M., Eckert, R.L. J. Invest. Dermatol. (2004) [Pubmed]
  13. Isoproterenol-induced myocardial injury resulting in altered S100A4 and S100A11 protein expression in the rat. Inamoto, S., Murao, S., Yokoyama, M., Kitazawa, S., Maeda, S. Pathol. Int. (2000) [Pubmed]
  14. Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments. Bianchi, R., Giambanco, I., Arcuri, C., Donato, R. Microsc. Res. Tech. (2003) [Pubmed]
  15. Calcium-dependent translocation of S100A11 requires tubulin filaments. Davey, G.E., Murmann, P., Hoechli, M., Tanaka, T., Heizmann, C.W. Biochim. Biophys. Acta (2000) [Pubmed]
  16. Identification of transglutaminase-reactive residues in S100A11. Robinson, N.A., Eckert, R.L. J. Biol. Chem. (1998) [Pubmed]
  17. S100 protein subcellular localization during epidermal differentiation and psoriasis. Broome, A.M., Ryan, D., Eckert, R.L. J. Histochem. Cytochem. (2003) [Pubmed]
  18. High expression of calcium-binding proteins, S100A10, S100A11 and CALM2 in anaplastic large cell lymphoma. Rust, R., Visser, L., van der Leij, J., Harms, G., Blokzijl, T., Deloulme, J.C., van der Vlies, P., Kamps, W., Kok, K., Lim, M., Poppema, S., van den Berg, A. Br. J. Haematol. (2005) [Pubmed]
  19. Involvement of interferon regulatory factor 1 and S100C/A11 in growth inhibition by transforming growth factor beta 1 in human hepatocellular carcinoma cells. Miyazaki, M., Sakaguchi, M., Akiyama, I., Sakaguchi, Y., Nagamori, S., Huh, N.H. Cancer Res. (2004) [Pubmed]
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