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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a.

Cyclooxygenase-2 ( COX-2) is expressed early in colon carcinogenesis and is known to play a crucial role in the progress of the disease. Here we show that the regulation of the expression of this enzyme in a colon cancer cell line, and in patients, is associated with overexpression of the Wnt pathway-associated proteins, Pontin52/TIP49a and LEF-1. Recently shown to be essential for transformation via the c-Myc pathway, Pontin52/TIP49a promotes COX-2 expression in tissue culture and is overexpressed in colon cancer tissue, co-localizing with COX-2 expression in transformed tissue, relative to paired normal tissue.[1]


  1. Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. Carlson, M.L., Wilson, E.T., Prescott, S.M. Mol. Cancer (2003) [Pubmed]
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