Gene Review:
LEF1 - lymphoid enhancer-binding factor 1
Homo sapiens
Synonyms:
LEF-1, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1-alpha, TCF10, ...
- Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Hovanes, K., Li, T.W., Munguia, J.E., Truong, T., Milovanovic, T., Lawrence Marsh, J., Holcombe, R.F., Waterman, M.L. Nat. Genet. (2001)
- Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation. Sekine, S., Takata, T., Shibata, T., Mori, M., Morishita, Y., Noguchi, M., Uchida, T., Kanai, Y., Hirohashi, S. Histopathology (2004)
- Loss of expression of the WNT/beta-catenin-signaling pathway transcription factors lymphoid enhancer factor-1 (LEF-1) and T cell factor-1 (TCF-1) in a subset of peripheral T cell lymphomas. Dorfman, D.M., Greisman, H.A., Shahsafaei, A. Am. J. Pathol. (2003)
- The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Giese, K., Cox, J., Grosschedl, R. Cell (1992)
- Human sebaceous tumors harbor inactivating mutations in LEF1. Takeda, H., Lyle, S., Lazar, A.J., Zouboulis, C.C., Smyth, I., Watt, F.M. Nat. Med. (2006)
- LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Skokowa, J., Cario, G., Uenalan, M., Schambach, A., Germeshausen, M., Battmer, K., Zeidler, C., Lehmann, U., Eder, M., Baum, C., Grosschedl, R., Stanulla, M., Scherr, M., Welte, K. Nat. Med. (2006)
- A yeast model system for functional analysis of beta-catenin signaling. Lee, M.S., D'Amour, K.A., Papkoff, J. J. Cell Biol. (2002)
- Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Labbé, E., Letamendia, A., Attisano, L. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator. Billin, A.N., Thirlwell, H., Ayer, D.E. Mol. Cell. Biol. (2000)
- An internal ribosome entry site mediates translation of lymphoid enhancer factor-1. Jimenez, J., Jang, G.M., Semler, B.L., Waterman, M.L. RNA (2005)
- Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. Willinger, T., Freeman, T., Herbert, M., Hasegawa, H., McMichael, A.J., Callan, M.F. J. Immunol. (2006)
- A novel isoform of human lymphoid enhancer-binding factor-1 (LEF-1) gene transcript encodes a protein devoid of HMG domain and nuclear localization signal. Kobielak, A., Kobielak, K., Trzeciak, W.H. Acta Biochim. Pol. (2001)
- Cell-specific expression of helix-loop-helix transcription factors encoded by the E2A gene. Aronheim, A., Shiran, R., Rosen, A., Walker, M.D. Nucleic Acids Res. (1993)
- Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Ishitani, T., Ninomiya-Tsuji, J., Matsumoto, K. Mol. Cell. Biol. (2003)
- Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells. Ki, H., Jung, H.C., Park, J.H., Kim, J.S., Lee, K.Y., Kim, T.S., Kim, K. Cell Biol. Int. (2006)
- {beta}-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells. Pan, W., Jia, Y., Huang, T., Wang, J., Tao, D., Gan, X., Li, L. J. Cell. Sci. (2006)
- Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling. Yasumoto, K., Takeda, K., Saito, H., Watanabe, K., Takahashi, K., Shibahara, S. EMBO J. (2002)
- A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. Waterman, M.L., Fischer, W.H., Jones, K.A. Genes Dev. (1991)
- A second protein kinase CK1-mediated step negatively regulates Wnt signalling by disrupting the lymphocyte enhancer factor-1/beta-catenin complex. Hämmerlein, A., Weiske, J., Huber, O. Cell. Mol. Life Sci. (2005)
- A new beta-catenin-dependent activation domain in T cell factor. Atcha, F.A., Munguia, J.E., Li, T.W., Hovanes, K., Waterman, M.L. J. Biol. Chem. (2003)
- Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways. Letamendia, A., Labbé, E., Attisano, L. The Journal of bone and joint surgery. American volume. (2001)
- Identification of MYCBP as a beta-catenin/LEF-1 target using DNA microarray analysis. Jung, H.C., Kim, K. Life Sci. (2005)
- Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Salins, P., Shawesh, S., He, Y., Dibrov, A., Kashour, T., Arthur, G., Amara, F. Neurosci. Lett. (2007)
- Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c-myc expression in the absence of TGF-beta signaling. Lim, S.K., Hoffmann, F.M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. Kato, T., Satoh, S., Okabe, H., Kitahara, O., Ono, K., Kihara, C., Tanaka, T., Tsunoda, T., Yamaoka, Y., Nakamura, Y., Furukawa, Y. Neoplasia (2001)
- Developmental expression of catenins and associated proteins during submucosal gland morphogenesis in the airway. Ritchie, T.C., Zhou, W., McKinstry, E., Hosch, M., Zhang, Y., Nathke, I., Engelhardt, J.F. Exp. Lung Res. (2001)
- Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts. Kahler, R.A., Galindo, M., Lian, J., Stein, G.S., van Wijnen, A.J., Westendorf, J.J. J. Cell. Biochem. (2006)
- Alterations of lymphoid enhancer factor-1 isoform expression in solid tumors and acute leukemias. Wang, W., Ji, P., Steffen, B., Metzger, R., Schneider, P.M., Halfter, H., Schrader, M., Berdel, W.E., Serve, H., Müller-Tidow, C. Acta Biochim. Biophys. Sin. (Shanghai) (2005)