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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Genetic knock out of 60kD Ro (or SSA), a common lupus autoantigen, induces lupus.

Systemic lupus erythematosus ( SLE) could have the most complicated phenotype and the most diverse genetics of any genetically complex human disease. Recent research shows that genetic ablation of the gene encoding 60kD Ro, a common autoantigen for SLE patients, results in an SLE-like illness in Ro-/- mice. These data add to the expanding cooperation between mouse and human SLE genetic studies and are the first in which ablation of an autoantigen induces an autoimmune disease.[1]

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