- Comparison of efficacy, safety, and cost of low-molecular-weight heparin with continuous-infusion unfractionated heparin for initiation of anticoagulation after mechanical prosthetic valve implantation. Fanikos, J., Tsilimingras, K., Kucher, N., Rosen, A.B., Hieblinger, M.D., Goldhaber, S.Z. Am. J. Cardiol. (2004)