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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Heart Valves

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Disease relevance of Heart Valves


Psychiatry related information on Heart Valves

  • They are consistent with the hypothesis that brain hypoperfusion contributes to dementia, possibly to AD pathogenesis, and raise the possibility that the APOE allele epsilon 4 contributes directly to heart valve and myocardial damage [6].

High impact information on Heart Valves


Chemical compound and disease context of Heart Valves


Biological context of Heart Valves


Anatomical context of Heart Valves


Associations of Heart Valves with chemical compounds


Gene context of Heart Valves

  • Gata4(ki/ki) mice die just after embryonic day (E) 12.5 exhibiting features in common with Fog2(-/-) embryos as well as additional semilunar cardiac valve defects and a double-outlet right ventricle [27].
  • Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa [28].
  • Nfatc1 is an endocardial transcription factor required for development of cardiac valves [17].
  • PTH(1-34) suppressed aortic OPN and Msx2 expression >50% and decreased cardiac valve calcification 80% (8.3 +/- 1.5% versus 1.4 +/- 0.5%; p < 0.001) [29].
  • In the present study, a frequently used control gene, beta-actin, was examined in ovine heart valves to evaluate its applicability as a housekeeping gene for this tissue [30].

Analytical, diagnostic and therapeutic context of Heart Valves


  1. A comparison of aspirin with placebo in patients treated with warfarin after heart-valve replacement. Turpie, A.G., Gent, M., Laupacis, A., Latour, Y., Gunstensen, J., Basile, F., Klimek, M., Hirsh, J. N. Engl. J. Med. (1993) [Pubmed]
  2. Hemostatic effect of tranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery. Sindet-Pedersen, S., Ramström, G., Bernvil, S., Blombäck, M. N. Engl. J. Med. (1989) [Pubmed]
  3. A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation. Jick, H., Vasilakis, C., Weinrauch, L.A., Meier, C.R., Jick, S.S., Derby, L.E. N. Engl. J. Med. (1998) [Pubmed]
  4. A role for smad6 in development and homeostasis of the cardiovascular system. Galvin, K.M., Donovan, M.J., Lynch, C.A., Meyer, R.I., Paul, R.J., Lorenz, J.N., Fairchild-Huntress, V., Dixon, K.L., Dunmore, J.H., Gimbrone, M.A., Falb, D., Huszar, D. Nat. Genet. (2000) [Pubmed]
  5. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. de la Pompa, J.L., Timmerman, L.A., Takimoto, H., Yoshida, H., Elia, A.J., Samper, E., Potter, J., Wakeham, A., Marengere, L., Langille, B.L., Crabtree, G.R., Mak, T.W. Nature (1998) [Pubmed]
  6. Cardiovascular damage in Alzheimer disease: autopsy findings from the Bryan ADRC. Corder, E.H., Ervin, J.F., Lockhart, E., Szymanski, M.H., Schmechel, D.E., Hulette, C.M. J. Biomed. Biotechnol. (2005) [Pubmed]
  7. Sculpting heart valves with NFATc and VEGF. Lambrechts, D., Carmeliet, P. Cell (2004) [Pubmed]
  8. An assessment of heart-valve abnormalities in obese patients taking dexfenfluramine, sustained-release dexfenfluramine, or placebo. Sustained-Release Dexfenfluramine Study Group. Weissman, N.J., Tighe, J.F., Gottdiener, J.S., Gwynne, J.T. N. Engl. J. Med. (1998) [Pubmed]
  9. Warfarin and aspirin after heart-valve replacement. Bussey, H.I., Linn, W.D. N. Engl. J. Med. (1994) [Pubmed]
  10. The transcription factor NF-ATc is essential for cardiac valve formation. Ranger, A.M., Grusby, M.J., Hodge, M.R., Gravallese, E.M., de la Brousse, F.C., Hoey, T., Mickanin, C., Baldwin, H.S., Glimcher, L.H. Nature (1998) [Pubmed]
  11. Prelesional events in atherogenesis. Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit. Simionescu, N., Vasile, E., Lupu, F., Popescu, G., Simionescu, M. Am. J. Pathol. (1986) [Pubmed]
  12. Impaired elastogenesis in Hurler disease: dermatan sulfate accumulation linked to deficiency in elastin-binding protein and elastic fiber assembly. Hinek, A., Wilson, S.E. Am. J. Pathol. (2000) [Pubmed]
  13. Selection and results of antiplatelet therapy in the prevention of stroke and myocardial infarction. Hirsh, J. Arch. Intern. Med. (1981) [Pubmed]
  14. Myths of dental-induced endocarditis. Wahl, M.J. Arch. Intern. Med. (1994) [Pubmed]
  15. Localized gene delivery using antibody tethered adenovirus from polyurethane heart valve cusps and intra-aortic implants. Stachelek, S.J., Song, C., Alferiev, I., Defelice, S., Cui, X., Connolly, J.M., Bianco, R.W., Levy, R.J. Gene Ther. (2004) [Pubmed]
  16. Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Iwamoto, R., Yamazaki, S., Asakura, M., Takashima, S., Hasuwa, H., Miyado, K., Adachi, S., Kitakaze, M., Hashimoto, K., Raab, G., Nanba, D., Higashiyama, S., Hori, M., Klagsbrun, M., Mekada, E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  17. Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Zhou, B., Wu, B., Tompkins, K.L., Boyer, K.L., Grindley, J.C., Baldwin, H.S. Development (2005) [Pubmed]
  18. TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis. Akhurst, R.J., Lehnert, S.A., Faissner, A., Duffie, E. Development (1990) [Pubmed]
  19. Alkaline phosphatase activity of glutaraldehyde-treated bovine pericardium used in bioprosthetic cardiac valves. Maranto, A.R., Schoen, F.J. Circ. Res. (1988) [Pubmed]
  20. periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Rios, H., Koushik, S.V., Wang, H., Wang, J., Zhou, H.M., Lindsley, A., Rogers, R., Chen, Z., Maeda, M., Kruzynska-Frejtag, A., Feng, J.Q., Conway, S.J. Mol. Cell. Biol. (2005) [Pubmed]
  21. Aluminum chloride pretreatment of elastin inhibits elastolysis by matrix metalloproteinases and leads to inhibition of elastin-oriented calcification. Bailey, M., Xiao, H., Ogle, M., Vyavahare, N. Am. J. Pathol. (2001) [Pubmed]
  22. Structural remodeling in hypertensive heart disease and the role of hormones. Weber, K.T., Sun, Y., Guarda, E. Hypertension (1994) [Pubmed]
  23. Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Schulz, R.A., Yutzey, K.E. Dev. Biol. (2004) [Pubmed]
  24. Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate. Levy, R.J., Wolfrum, J., Schoen, F.J., Hawley, M.A., Lund, S.A., Langer, R. Science (1985) [Pubmed]
  25. Cardiac catabolic factors: the degradation of heart valve intercellular matrix. Decker, R.S., Dingle, J.T. Science (1982) [Pubmed]
  26. Adherence of glucan-positive and glucan-negative streptococcal strains to normal and damaged heart valves. Ramirez-Ronda, C.H. J. Clin. Invest. (1978) [Pubmed]
  27. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Crispino, J.D., Lodish, M.B., Thurberg, B.L., Litovsky, S.H., Collins, T., Molkentin, J.D., Orkin, S.H. Genes Dev. (2001) [Pubmed]
  28. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Akiyama, H., Chaboissier, M.C., Behringer, R.R., Rowitch, D.H., Schedl, A., Epstein, J.A., de Crombrugghe, B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  29. Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient mice. Shao, J.S., Cheng, S.L., Charlton-Kachigian, N., Loewy, A.P., Towler, D.A. J. Biol. Chem. (2003) [Pubmed]
  30. Beta-actin cannot be used as a control for gene expression in ovine interstitial cells derived from heart valves. Yperman, J., De Visscher, G., Holvoet, P., Flameng, W. J. Heart Valve Dis. (2004) [Pubmed]
  31. The role of glutaraldehyde-induced cross-links in calcification of bovine pericardium used in cardiac valve bioprostheses. Golomb, G., Schoen, F.J., Smith, M.S., Linden, J., Dixon, M., Levy, R.J. Am. J. Pathol. (1987) [Pubmed]
  32. Failure of adjusted doses of subcutaneous heparin to prevent thromboembolic phenomena in pregnant patients with mechanical cardiac valve prostheses. Salazar, E., Izaguirre, R., Verdejo, J., Mutchinick, O. J. Am. Coll. Cardiol. (1996) [Pubmed]
  33. Risks and benefits of adding anti-platelet therapy to warfarin among patients with prosthetic heart valves: a meta-analysis. Massel, D., Little, S.H. J. Am. Coll. Cardiol. (2001) [Pubmed]
  34. Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Price, P.A., Faus, S.A., Williamson, M.K. Arterioscler. Thromb. Vasc. Biol. (1998) [Pubmed]
  35. Storage of heart valve allografts in glycerol with subsequent antibiotic sterilisation. Parker, R., Randev, R., Wain, W.H., Ross, D.N. Thorax (1978) [Pubmed]
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