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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Length of Stay

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Disease relevance of Length of Stay


Psychiatry related information on Length of Stay

  • There was a significant difference between employed and non-employed groups in terms of GCS, post-traumatic amnesia (PTA), in-patient rehabilitation length of stay (LOS) and GOS at 6 and at 12 months post-injury [6].

High impact information on Length of Stay

  • Admission illness severity, average length of stay, and admission albumin and prealbumin levels for this low nutrient group did not differ significantly from those of the remaining patients [7].
  • For the five diseases combined; length of stay dropped 24% and in-hospital mortality declined from 16.1% to 12.6% after the PPS was introduced (P less than .05) [8].
  • To examine this possibility we studied the case mix, length of stay, and number of procedures for 65,032 patients listed as self-pay or free care, Blue Cross, or Medicaid at 52 hospitals in the Boston, Mass, area during 1983 [9].
  • Although patients admitted to fellowship hospitals tended to have a higher severity of illness, both unadjusted (6.3 +/- 9.0 vs. 7.1 +/- 7.5 days; P < 0.01) and risk-adjusted length of stay were somewhat shorter [10].
  • Dimensions of psychosocial problem severity and length of stay are, therefore, important considerations in the treatment of cocaine dependence [11].

Chemical compound and disease context of Length of Stay


Biological context of Length of Stay


Anatomical context of Length of Stay

  • Patients with leukocyte filters had the following findings compared with nonfilter patients: The time to extubation 10.3 versus 16.2 hours (P = 0.009), postoperative respiratory quotient 407 versus 320 (P = 0.02), total length of stay 5.4 versus 7.2 days (P = 0.04) [22].
  • OBJECTIVES: To examine the frequency and reasons for rehospitalization in persons with acute traumatic spinal cord injury (SCI) during follow-up years and to examine the association between rehospitalization and demographics, neurologic category, payer sources, length of stay (LOS), discharge motor FIM instrument score, and discharge residence [23].
  • There was a significant difference with respect to Injury Severity Score, Glasgow Coma Scale score, Revised Trauma Score, units of packed red blood cells transfused, length of stay, intensive care unit length of stay, mean splenic injury grade, and cost between patients observed initially and those operated on initially [24].
  • Background factors, such as ISS, AIS scores for various trauma sites, length of stay in ICU and length of ventilatory days, as well as the fungal culture derived from blood, sputum, urine and pharyngeal smear, and the serological diagnosis were compared for the seven groups [25].
  • CONCLUSION: Mitral valve plasty for MR is efficient and associated with shorter CPB and ischemia times as well as length of stay in ICU, together with a lower device cost, which makes MVP more cost effective than MVR [26].

Associations of Length of Stay with chemical compounds

  • In multivariable models, oral-only patients had a median length of stay that was 1.3 days shorter (95% CI: 0.4% to 2.2% days; P = 0.008) and a median antibiotic cost that was 56 dollars lower (95% CI: 53 dollars to 58 dollars; P <0.0001) than that of patients in the parenteral group, but mortality was similar [27].
  • CONCLUSIONS: Heparin infusion after successful coronary intervention is associated with more minor bleeding and vascular injury, prolonged length of stay and increased cost [28].
  • LAAM was as effective as methadone on all outcome measures, including length of stay in treatment [29].
  • Median length of stay was 32 (23-52) days on glutamine, which was not significantly different from the control value of 35 (25-55) days [30].
  • CONCLUSIONS: Predischarge initiation of carvedilol in stabilized patients hospitalized for HF improved the use of beta-blockade at 60 days without increasing side effects or length of stay [31].

Gene context of Length of Stay

  • In the NINDS rt-PA Stroke Trial, the average length of stay was significantly shorter in tPA-treated patients than in placebo-treated patients (10.9 versus 12.4 days; p = 0.02) and more tPA patients were discharged to home than to inpatient rehabilitation or a nursing home (48% versus 36%; p = 0.002) [32].
  • Mean length of stay decreased (2.7 days for wave 1, 2.2 days for wave 3, p <0.001) [33].
  • During bacteremia, IL-8 also correlated well with patient use of a ventilator (P < 0.01, OR = 2.43, CI = 2.41-311.19), use of vasopressors (P < 0.05, OR = 2.67, CI = 1.79-370.78), length of stay in the hospital (P < 0.01, OR = 3.14, CI = 1.87-988.31), and stay in the ICU (P < 0.01, OR = 2.51, CI = 2.98-449.80) [34].
  • For the case-control study, cases were defined as patients with MRSA BSI; control patients with MSSA BSI were selected in a stepwise manner according to the following matching variables: age, sex, number of comorbidities, severity of underlying illness, and prior length of stay in the hospital [35].
  • Data on process and outcome of care (death and length of stay) were collected retrospectively at 90 days on all prospectively identified COPD admissions over an 8 week period [36].

Analytical, diagnostic and therapeutic context of Length of Stay


  1. Randomised clinical trial of perioperative cefazolin in preventing infection after hysterectomy. Polk, B.F., Tager, I.B., Shapiro, M., Goren-White, B., Goldstein, P., Schoenbaum, S.C. Lancet (1980) [Pubmed]
  2. Outcomes of hospitalizations for myocardial infarctions and cerebrovascular accidents in patients with systemic lupus erythematosus. Ward, M.M. Arthritis Rheum. (2004) [Pubmed]
  3. Health and economic outcomes of vancomycin-resistant enterococci. Carmeli, Y., Eliopoulos, G., Mozaffari, E., Samore, M. Arch. Intern. Med. (2002) [Pubmed]
  4. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Nathens, A.B., Neff, M.J., Jurkovich, G.J., Klotz, P., Farver, K., Ruzinski, J.T., Radella, F., Garcia, I., Maier, R.V. Ann. Surg. (2002) [Pubmed]
  5. Mortality following hip fracture before and after implementation of the prospective payment system. Ray, W.A., Griffin, M.R., Baugh, D.K. Arch. Intern. Med. (1990) [Pubmed]
  6. Reintegration after severe brain injury: a retrospective study. Avesani, R., Salvi, L., Rigoli, G., Gambini, M.G. Brain injury : [BI]. (2005) [Pubmed]
  7. Protein-energy undernutrition among elderly hospitalized patients: a prospective study. Sullivan, D.H., Sun, S., Walls, R.C. JAMA (1999) [Pubmed]
  8. Comparing outcomes of care before and after implementation of the DRG-based prospective payment system. Kahn, K.L., Keeler, E.B., Sherwood, M.J., Rogers, W.H., Draper, D., Bentow, S.S., Reinisch, E.J., Rubenstein, L.V., Kosecoff, J., Brook, R.H. JAMA (1990) [Pubmed]
  9. Case mix and resource utilization by uninsured hospital patients in the Boston metropolitan area. Weissman, J., Epstein, A.M. JAMA (1989) [Pubmed]
  10. Care of patients with upper gastrointestinal hemorrhage in academic medical centers: a community-based comparison. Cooper, G.S., Chak, A., Harper, D.L., Pine, M., Rosenthal, G.E. Gastroenterology (1996) [Pubmed]
  11. A national evaluation of treatment outcomes for cocaine dependence. Simpson, D.D., Joe, G.W., Fletcher, B.W., Hubbard, R.L., Anglin, M.D. Arch. Gen. Psychiatry (1999) [Pubmed]
  12. Predictors of acute hospital costs for treatment of ischemic stroke in an academic center. Diringer, M.N., Edwards, D.F., Mattson, D.T., Akins, P.T., Sheedy, C.W., Hsu, C.Y., Dromerick, A.W. Stroke (1999) [Pubmed]
  13. Risk factors for nosocomial infection in critically ill children: a prospective cohort study. Singh-Naz, N., Sprague, B.M., Patel, K.M., Pollack, M.M. Crit. Care Med. (1996) [Pubmed]
  14. The hospital cost of congenital syphilis. Bateman, D.A., Phibbs, C.S., Joyce, T., Heagarty, M.C. J. Pediatr. (1997) [Pubmed]
  15. Intermittent inflow occlusion in living liver donors: impact on safety and remnant function. Miller, C.M., Masetti, M., Cautero, N., DiBenedetto, F., Lauro, A., Romano, A., Quintini, C., Siniscalchi, A., Begliomini, B., Pinna, A.D. Liver Transpl. (2004) [Pubmed]
  16. Effect of antiemetic therapy on recovery and hospital discharge time. A double-blind assessment of ondansetron, droperidol, and placebo in pediatric patients undergoing ambulatory surgery. Davis, P.J., McGowan, F.X., Landsman, I., Maloney, K., Hoffmann, P. Anesthesiology (1995) [Pubmed]
  17. Postoperative troponin-T predicts prolonged intensive care unit length of stay following cardiac surgery. Baggish, A.L., MacGillivray, T.E., Hoffman, W., Newell, J.B., Lewandrowski, K.B., Lee-Lewandrowski, E., Anwaruddin, S., Siebert, U., Januzzi, J.L. Crit. Care Med. (2004) [Pubmed]
  18. Does patient-controlled analgesia achieve better control of pain and fewer adverse effects than intramuscular analgesia? A prospective randomized trial. Nitschke, L.F., Schlösser, C.T., Berg, R.L., Selthafner, J.V., Wengert, T.J., Avecilla, C.S. Archives of surgery (Chicago, Ill. : 1960) (1996) [Pubmed]
  19. Clinical correlations in infants in the neonatal intensive care unit with varying severity of gastroesophageal reflux. Khalaf, M.N., Porat, R., Brodsky, N.L., Bhandari, V. J. Pediatr. Gastroenterol. Nutr. (2001) [Pubmed]
  20. Toll of methamphetamine on the trauma system. Tominaga, G.T., Garcia, G., Dzierba, A., Wong, J. Archives of surgery (Chicago, Ill. : 1960) (2004) [Pubmed]
  21. Economic analysis of nosocomial infections in a Turkish university hospital. Yalçin, A.N., Hayran, M., Unal, S. Journal of chemotherapy (Florence, Italy) (1997) [Pubmed]
  22. Clinical benefits of leukocyte filtration during valve surgery. Patel, A.N., Sutton, S.W., Livingston, S., Patel, A., Hunley, E.K., Hebeler, R.F., Henry, A.C., Hamman, B.L., Wood, R.E., Urschel, H.C. Am. J. Surg. (2003) [Pubmed]
  23. Etiology and incidence of rehospitalization after traumatic spinal cord injury: a multicenter analysis. Cardenas, D.D., Hoffman, J.M., Kirshblum, S., McKinley, W. Archives of physical medicine and rehabilitation. (2004) [Pubmed]
  24. Overuse of splenic scoring and computed tomographic scans. Shapiro, M.J., Krausz, C., Durham, R.M., Mazuski, J.E. The Journal of trauma. (1999) [Pubmed]
  25. [Fungal infection in patients with serious disease. Risk analysis of fungal infection]. Tanaka, H., Huruhata, T., Gotou, H., Sakurai, M., Shimazaki, S. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology. (1999) [Pubmed]
  26. Economic impact of mitral valve plasty versus replacement for mitral valve insufficiency. Christenson, J.T., Kalangos, A. The Journal of cardiovascular surgery. (2003) [Pubmed]
  27. Efficacy of exclusively oral antibiotic therapy in patients hospitalized with nonsevere community-acquired pneumonia: a retrospective study and meta-analysis. Marras, T.K., Nopmaneejumruslers, C., Chan, C.K. Am. J. Med. (2004) [Pubmed]
  28. Heparin after percutaneous intervention (HAPI): a prospective multicenter randomized trial of three heparin regimens after successful coronary intervention. Rabah, M., Mason, D., Muller, D.W., Hundley, R., Kugelmass, A.D., Weiner, B., Cannon, L., O'Neill, W.W., Safian, R.D. J. Am. Coll. Cardiol. (1999) [Pubmed]
  29. A clinical, controlled study of l-alpha-acetylmethadol in the treatment of narcotic addiction. Marcovici, M., O'Brien, C.P., McLellan, A.T., Kacian, J. The American journal of psychiatry. (1981) [Pubmed]
  30. A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition. Powell-Tuck, J., Jamieson, C.P., Bettany, G.E., Obeid, O., Fawcett, H.V., Archer, C., Murphy, D.L. Gut (1999) [Pubmed]
  31. Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial. Gattis, W.A., O'Connor, C.M., Gallup, D.S., Hasselblad, V., Gheorghiade, M. J. Am. Coll. Cardiol. (2004) [Pubmed]
  32. Cost-effectiveness of tissue plasminogen activator for acute ischemic stroke. NINDS rt-PA Stroke Study Group. Fagan, S.C., Morgenstern, L.B., Petitta, A., Ward, R.E., Tilley, B.C., Marler, J.R., Levine, S.R., Broderick, J.P., Kwiatkowski, T.G., Frankel, M., Brott, T.G., Walker, M.D. Neurology (1998) [Pubmed]
  33. Importance of the postdischarge interval in assessing major adverse clinical event rates following percutaneous coronary intervention. Laskey, W.K., Selzer, F., Jacobs, A.K., Cohen, H.A., Holmes, D.R., Wilensky, R.L., Detre, K.M., Williams, D.O. Am. J. Cardiol. (2005) [Pubmed]
  34. Interleukin-8 as a predictor of the severity of bacteremia and infectious disease. Lin, K.J., Lin, J., Hanasawa, K., Tani, T., Kodama, M. Shock (2000) [Pubmed]
  35. Impact of methicillin resistance on the outcome of patients with bacteremia caused by Staphylococcus aureus. Harbarth, S., Rutschmann, O., Sudre, P., Pittet, D. Arch. Intern. Med. (1998) [Pubmed]
  36. Evidence for a link between mortality in acute COPD and hospital type and resources. Roberts, C.M., Barnes, S., Lowe, D., Pearson, M.G. Thorax (2003) [Pubmed]
  37. Influence of carvedilol on hospitalizations in heart failure: incidence, resource utilization and costs. U.S. Carvedilol Heart Failure Study Group. Fowler, M.B., Vera-Llonch, M., Oster, G., Bristow, M.R., Cohn, J.N., Colucci, W.S., Gilbert, E.M., Lukas, M.A., Lacey, M.J., Richner, R., Young, S.T., Packer, M. J. Am. Coll. Cardiol. (2001) [Pubmed]
  38. Factors influencing outcome and length of stay in a stroke rehabilitation unit. Part 2. Comparison of 318 screened and 248 unscreened patients. Feigenson, J.S., McCarthy, M.L., Greenberg, S.D., Feigenson, W.D. Stroke (1977) [Pubmed]
  39. Effect of simvastatin treatment on cardiovascular resource utilization in impaired fasting glucose and diabetes. Findings from the Scandinavian Simvastatin Survival Study. Herman, W.H., Alexander, C.M., Cook, J.R., Boccuzzi, S.J., Musliner, T.A., Pedersen, T.R., Kjekshus, J., Pyörälä, K. Diabetes Care (1999) [Pubmed]
  40. Anticoagulation with enoxaparin versus intravenous unfractionated heparin in postoperative vascular surgery patients. Hingorani, A., Gramse, C., Ascher, E. J. Vasc. Surg. (2002) [Pubmed]
  41. Fluconazole prophylaxis in critically ill surgical patients: a meta-analysis. Shorr, A.F., Chung, K., Jackson, W.L., Waterman, P.E., Kollef, M.H. Crit. Care Med. (2005) [Pubmed]
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