- The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT). Anlezark, G.M., Melton, R.G., Sherwood, R.F., Coles, B., Friedlos, F., Knox, R.J. Biochem. Pharmacol. (1992)