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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

pokkuri, a Drosophila gene encoding an E-26-specific ( Ets) domain protein, prevents overproduction of the R7 photoreceptor.

Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds. sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific ( Ets) domain.[1]


  1. pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor. Tei, H., Nihonmatsu, I., Yokokura, T., Ueda, R., Sano, Y., Okuda, T., Sato, K., Hirata, K., Fujita, S.C., Yamamoto, D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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