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Gene Review

aop  -  anterior open

Drosophila melanogaster

Synonyms: AOP, Aop, Aop/Yan, CG3166, DROYANET, ...
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High impact information on aop

  • Depolymerization of Yan by Mae represents a novel mechanism of transcriptional control that sensitizes Yan for regulation by receptor tyrosine kinases [1].
  • This interaction is cooperative when both proteins are targeted to the same promoter and is antagonized by another ETS domain protein, YAN, a negative regulator of R7 development [2].
  • This phosphorylation is both necessary and sufficient to abrogate transcriptional repression by Yan. Mae also regulates the activity of the transcriptional activator Pointed-P2 by a similar mechanism [3].
  • Furthermore, we present genetic and biochemical data suggesting that MAP kinase controls neural development through phosphorylation of two antagonizing transcription factors of the ETS family, Yan and PntP2 [4].
  • DJun and Aop regulate dpp expression in the most dorsal row of cells [5].

Biological context of aop


Anatomical context of aop


Physical interactions of aop


Enzymatic interactions of aop

  • Hyperstable Yan (ACT) cannot be phosphorylated and blocks prospero expression [7].

Regulatory relationships of aop


Other interactions of aop

  • In this way, Yan and Pointed are essential for prospero regulation [7].
  • The simultaneous effects of the DER pathway on pntP1 induction and Yan inactivation may contribute to the definition of the border of the ventralmost cell fates [10].
  • We demonstrate that the molecular mechanism underlying downregulation of YAN involves CRM1-mediated nuclear export and define a novel role in this context for MAE, a co-factor previously implicated in facilitating MAPK phosphorylation of YAN [16].
  • Thus, we propose that MAE plays multiple independent roles in fine-tuning the levels of POINTED and YAN activity in accordance with changing RTK signaling conditions [16].
  • Here, we show that Yan, an Ets transcriptional repressor that blocks cellular potential for specification and differentiation, is a target of Notch signaling during Drosophila eye development [17].


  1. Derepression by depolymerization; structural insights into the regulation of Yan by Mae. Qiao, F., Song, H., Kim, C.A., Sawaya, M.R., Hunter, J.B., Gingery, M., Rebay, I., Courey, A.J., Bowie, J.U. Cell (2004) [Pubmed]
  2. JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye. Treier, M., Bohmann, D., Mlodzik, M. Cell (1995) [Pubmed]
  3. Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila. Baker, D.A., Mille-Baker, B., Wainwright, S.M., Ish-Horowicz, D., Dibb, N.J. Nature (2001) [Pubmed]
  4. The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Brunner, D., Dücker, K., Oellers, N., Hafen, E., Scholz, H., Klämbt, C. Nature (1994) [Pubmed]
  5. Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Riesgo-Escovar, J.R., Hafen, E. Genes Dev. (1997) [Pubmed]
  6. Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response. Song, H., Nie, M., Qiao, F., Bowie, J.U., Courey, A.J. Genes Dev. (2005) [Pubmed]
  7. Yan regulates Lozenge during Drosophila eye development. Behan, K.J., Nichols, C.D., Cheung, T.L., Farlow, A., Hogan, B.M., Batterham, P., Pollock, J.A. Dev. Genes Evol. (2002) [Pubmed]
  8. Function of the ETS transcription factor Yan in border cell migration. Schober, M., Rebay, I., Perrimon, N. Development (2005) [Pubmed]
  9. pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor. Tei, H., Nihonmatsu, I., Yokokura, T., Ueda, R., Sano, Y., Okuda, T., Sato, K., Hirata, K., Fujita, S.C., Yamamoto, D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  10. EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. Gabay, L., Scholz, H., Golembo, M., Klaes, A., Shilo, B.Z., Klämbt, C. Development (1996) [Pubmed]
  11. MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN. Vivekanand, P., Tootle, T.L., Rebay, I. Mech. Dev. (2004) [Pubmed]
  12. The yan gene is highly conserved in Drosophila and its expression suggests a complex role throughout development. Price, M.D., Lai, Z. Dev. Genes Evol. (1999) [Pubmed]
  13. Tribolium mae expression suggests roles in terminal and midline patterning and in the specification of mesoderm. Bucher, G., Klingler, M. Dev. Genes Evol. (2005) [Pubmed]
  14. Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea. Ohshiro, T., Emori, Y., Saigo, K. Mech. Dev. (2002) [Pubmed]
  15. Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis. O'Keefe, L., Dougan, S.T., Gabay, L., Raz, E., Shilo, B.Z., DiNardo, S. Development (1997) [Pubmed]
  16. CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE. Tootle, T.L., Lee, P.S., Rebay, I. Development (2003) [Pubmed]
  17. Notch activation of yan expression is antagonized by RTK/pointed signaling in the Drosophila eye. Rohrbaugh, M., Ramos, E., Nguyen, D., Price, M., Wen, Y., Lai, Z.C. Curr. Biol. (2002) [Pubmed]
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