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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel.

In the course of finding Korean natural products with acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the twigs of Vaccinium oldhami significantly inhibited AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two compounds, taraxerol (1) and scopoletin (2), as active constituents. These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds 1 and 2 were 33.6 (79 microM) and 10.0 (52 microM) microg/mL, respectively.[1]


  1. Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel. Lee, J.H., Lee, K.T., Yang, J.H., Baek, N.I., Kim, D.K. Arch. Pharm. Res. (2004) [Pubmed]
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